Reid S D, Penna G, Adorini L
Roche Milano Ricerche, Milan, 20132, Italy.
Curr Opin Immunol. 2000 Feb;12(1):114-21. doi: 10.1016/s0952-7915(99)00059-x.
Dendritic cells are known as the most efficient antigen-presenting cell type to activate naïve T cells; however, they are able to do more than just efficiently present antigen to T cells. They are key modulators of the immune response that can influence Th cell differentiation by preferentially inducing Th type 1 or 2 cell responses, and the differential polarisation of CD4(+) T cells appears to be mediated by discrete dendritic cell subsets.
树突状细胞被认为是激活初始T细胞的最有效的抗原呈递细胞类型；然而，它们能做的不仅仅是有效地向T细胞呈递抗原。它们是免疫反应的关键调节因子，能够通过优先诱导1型或2型Th细胞反应来影响Th细胞分化，而CD4(+) T细胞的不同极化似乎由离散的树突状细胞亚群介导。
