蛋白质识别mRNA帽的结构基础。
Structural basis of mRNA cap recognition by proteins.
作者信息
Quiocho F A, Hu G, Gershon P D
机构信息
Department of Biochemistry and the Structural and Computational Biology, Howard Hughes Medical Institute, Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Curr Opin Struct Biol. 2000 Feb;10(1):78-86. doi: 10.1016/s0959-440x(99)00053-6.
Crystal structures have recently become available for two proteins (VP39 and eIF4E) complexed with their cognate ligand - the mRNA cap. Despite their total structural dissimilarity, both proteins bind N7-methylguanine between two parallel aromatic sidechains. The resulting stacked arrangement governs their high specificity for the alkylated form of the nucleobase.
最近已获得两种与同源配体——mRNA帽结合的蛋白质（VP39和eIF4E）的晶体结构。尽管它们的整体结构不同，但这两种蛋白质都在两条平行的芳香族侧链之间结合N7-甲基鸟嘌呤。由此产生的堆积排列决定了它们对碱基烷基化形式的高特异性。
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