Bonde J, Antonsen K, Henneberg S W, Uhrbrandt B, Wanscher M C
Anaestesiologisk afdeling, Amtssygehuset i Herlev.
Ugeskr Laeger. 2000 Jan 17;162(3):335-9.
Inhaled nitric oxide (iNO) has been extensively used in the treatment of severe hypoxaemic respiratory failure and/or pulmonary hypertension. Although the majority of studies have almost consistently demonstrated a beneficial effect on oxygenation and a reduction in pulmonary artery pressures, none of the randomised trials have reported a reduced mortality using iNO on patients with severe respiratory failure. In neonates with severe respiratory failure and pulmonary hypertension, however, iNO can reduce the need of extracorporal membrane oxygenation. Prior to using iNO on adult patients we suggest other measures to be taken (i.e. optimising ventilator settings, ventilation in prone position).
吸入一氧化氮（iNO）已广泛用于治疗严重低氧血症性呼吸衰竭和/或肺动脉高压。尽管大多数研究几乎一致证明其对氧合有有益作用且能降低肺动脉压力，但尚无随机试验报告使用iNO可降低严重呼吸衰竭患者的死亡率。然而，在患有严重呼吸衰竭和肺动脉高压的新生儿中，iNO可减少体外膜肺氧合的需求。在对成年患者使用iNO之前，我们建议采取其他措施（即优化呼吸机设置、俯卧位通气）。
