Knosalla C, Weng Y, Yankah A C, Siniawski H, Hofmeister J, Hammerschmidt R, Loebe M, Hetzer R
Department of Cardiothoracic and Vascular Surgery, German Heart Institute, Berlin, Germany.
Eur Heart J. 2000 Mar;21(6):490-7. doi: 10.1053/euhj.1999.1877.
The aim of the study was to evaluate the long-term results of allograft and prosthetic valve replacement in the treatment of infective aortic valve endocarditis with periannular abscess.
Between March 1988 and March 1996, 65 patients underwent surgery for active aortic valve endocarditis and paravalvular abscess. The indications for surgery were congestive heart failure, systemic emboli and atrioventricular block III. The pre-operative evaluation was performed with transoesophageal echocardiography. Aortic valve replacement was performed with allografts in 47 cases, with mechanical valves in 15, and bioprosthetic valves in three cases. All patients with total ventricular-aortic dehiscence and prosthetic valve endocarditis were treated with allografts.
The 30-day mortality rate was 23.5% in the prosthetic group, when compared with 8.5% in the patients treated with allografts. The rate of recurrent valve infections during the 11-year follow-up period was 27.1% in the prosthetic group and 3.2% in the allograft group. The actuarial 11-year survival rate was 82.1% in the allograft group and 64.7% in the prosthetic group.
Aortic allografts are an effective treatment for infective aortic valve endocarditis with associated periannular abscess. The operative mortality and recurrent infection rates are lower than in the prosthetic group, resulting in a significantly higher survival rate. Diagnosis and surgical management of these cases should be based on pre-operative transoesophageal echocardiography.
本研究旨在评估同种异体移植物和人工瓣膜置换术治疗感染性主动脉瓣心内膜炎合并瓣周脓肿的长期疗效。
1988年3月至1996年3月期间,65例患者因活动性主动脉瓣心内膜炎和瓣周脓肿接受手术。手术指征为充血性心力衰竭、系统性栓塞和三度房室传导阻滞。术前采用经食管超声心动图进行评估。47例患者采用同种异体移植物进行主动脉瓣置换,15例采用机械瓣膜,3例采用生物瓣膜。所有全室-主动脉瓣裂开和人工瓣膜心内膜炎患者均采用同种异体移植物治疗。
人工瓣膜组30天死亡率为23.5%,而异种移植患者为8.5%。在11年的随访期内,人工瓣膜组瓣膜感染复发率为27.1%,同种异体移植组为3.2%。同种异体移植组11年精算生存率为82.1%;人工瓣膜组为64.7%。
同种异体主动脉移植物是治疗感染性主动脉瓣心内膜炎合并瓣周脓肿的有效方法。手术死亡率和感染复发率低于人工瓣膜组,生存率显著更高。这些病例的诊断和手术管理应基于术前经食管超声心动图。