Miller J B
J Reprod Med. 1976 Oct;17(4):217-24.
Chronic myelocytic leukemia and the myeloproliferative diseases may present as asymptomatic elevations of peripheral blood counts or with relatively nonspecific symptoms. Full diagnostic evaluation is necessary to eliminate the many other causes of blood count elevation. Coincidence of a myeloproliferative disease and pregnancy is unusual. The pregnancy has no adverse effect on the course of the mother's hematologic disease. However, the myeloproliferative diseases, especially if uncontrolled, result in increased fetal prematurity and mortality. Treatment of the pregnant patient should be conservative, and cytotoxic therapy should be avoided until at least after the first trimester whenever possible. Busulfan has been the drug most widely used during pregnancy, and it appears not to cause fetal malformations when used alone.
慢性粒细胞白血病和骨髓增殖性疾病可能表现为外周血细胞计数无症状性升高或伴有相对非特异性的症状。进行全面的诊断评估对于排除血细胞计数升高的许多其他原因是必要的。骨髓增殖性疾病与妊娠同时存在的情况并不常见。妊娠对母亲血液系统疾病的病程没有不利影响。然而，骨髓增殖性疾病，尤其是如果未得到控制，会导致胎儿早产和死亡率增加。对孕妇的治疗应该保守，并且只要有可能，应避免在孕早期至少结束前进行细胞毒性治疗。白消安一直是孕期使用最广泛的药物，单独使用时似乎不会导致胎儿畸形。
