Agonist binding to G-protein coupled receptors.
作者信息
Strange P G
机构信息
School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, RG6 6AJ.
出版信息
Br J Pharmacol. 2000 Feb;129(4):820-1. doi: 10.1038/sj.bjp.0702991.
Abstract
摘要
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Molecular Architecture of G Protein-Coupled Receptors.G蛋白偶联受体的分子结构
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G-protein coupled receptors: conformations and states.G蛋白偶联受体：构象与状态
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Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors.结合、门控、亲和力与效能：激动剂的构效关系解读及受体突变效应
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Three-state and two-state models.三态和二态模型。
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Functional microdomains in G-protein-coupled receptors. The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor.G蛋白偶联受体中的功能微区。促性腺激素释放激素受体中保守的精氨酸笼基序。
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The energetics of ligand binding at catecholamine receptors.儿茶酚胺受体处配体结合的能量学
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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.与鸟嘌呤核苷酸调节蛋白偶联的受体的组成性活性。
Trends Pharmacol Sci. 1993 Aug;14(8):303-7. doi: 10.1016/0165-6147(93)90048-O.
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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.β2肾上腺素能受体的突变诱导激活状态。扩展三元复合物模型。
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Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.
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