• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Agonist binding to G-protein coupled receptors.

作者信息

Strange P G

机构信息

School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, RG6 6AJ.

出版信息

Br J Pharmacol. 2000 Feb;129(4):820-1. doi: 10.1038/sj.bjp.0702991.

DOI:10.1038/sj.bjp.0702991
PMID:10683207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1571878/
Abstract
摘要

相似文献

1
Agonist binding to G-protein coupled receptors.激动剂与G蛋白偶联受体的结合。
Br J Pharmacol. 2000 Feb;129(4):820-1. doi: 10.1038/sj.bjp.0702991.
2
G-protein-coupled receptors: what limits high-affinity agonist binding?
Trends Pharmacol Sci. 2000 Mar;21(3):82-4. doi: 10.1016/s0165-6147(99)01426-1.
3
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.G蛋白偶联受体的组成性活性：疾病病因与野生型受体的共同特性
Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):381-416. doi: 10.1007/s00210-002-0588-0. Epub 2002 Sep 6.
4
Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery.G蛋白偶联受体的反向激动作用：（病理）生理学相关性及对药物发现的影响
Br J Pharmacol. 2000 May;130(1):1-12. doi: 10.1038/sj.bjp.0703311.
5
Agonist induction and conformational selection during activation of a G-protein-coupled receptor.G蛋白偶联受体激活过程中的激动剂诱导与构象选择
Trends Pharmacol Sci. 2003 Feb;24(2):81-6. doi: 10.1016/S0165-6147(02)00050-0.
6
Mechanisms of inverse agonism at G-protein-coupled receptors.G蛋白偶联受体反向激动作用的机制。
Trends Pharmacol Sci. 2002 Feb;23(2):89-95. doi: 10.1016/s0165-6147(02)01993-4.
7
Considerations in the evaluation of inverse agonism and protean agonism at G protein-coupled receptors.G蛋白偶联受体反向激动作用和多面激动作用评估中的注意事项。
Methods Enzymol. 2002;343:3-16. doi: 10.1016/s0076-6879(02)43124-2.
8
Drug analysis based on signaling responses to G-protein-coupled receptors.基于对G蛋白偶联受体信号反应的药物分析。
J Recept Signal Transduct Res. 2001 May-Aug;21(2-3):167-90. doi: 10.1081/rrs-100107427.
9
Agonist-induced high-affinity GTP hydrolysis as an index of receptor-mediated G protein activation in mammalian brain membranes.激动剂诱导的高亲和力GTP水解作为哺乳动物脑膜中受体介导的G蛋白激活的指标。
Methods Mol Biol. 1997;83:133-41. doi: 10.1385/0-89603-495-X:133.
10
Use of constitutive G protein-coupled receptor activity for drug discovery.组成型G蛋白偶联受体活性在药物发现中的应用。
Mol Pharmacol. 2000 Jan;57(1):125-34.

引用本文的文献

1
Pharmacology and structure of isolated conformations of the adenosine A₂A receptor define ligand efficacy.分离的腺苷 A₂A 受体构象的药理学和结构定义了配体的效力。
Mol Pharmacol. 2013 May;83(5):949-58. doi: 10.1124/mol.112.084509. Epub 2013 Feb 19.
2
Evaluation of [C]S14506 and [F]S14506 in rat and monkey as agonist PET radioligands for brain 5-HT(1A) receptors.评估[C]S14506和[F]S14506作为脑5-羟色胺（5-HT）(1A)受体激动剂PET放射性配体在大鼠和猴子体内的情况。
Curr Radiopharm. 2010 Jan;3(1):9-18. doi: 10.2174/1874471011003010009.
3
Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats.1-（2,5-二甲氧基-4-甲基苯基）-2-氨基丙烷（DOM）、酮色林和（R）-（+）-{α}-（2,3-二甲氧基苯基）-1-[2-（4-氟苯基）乙基]-4-哌啶甲醇（MDL100907）对大鼠的辨别性刺激作用
J Pharmacol Exp Ther. 2009 Nov;331(2):671-9. doi: 10.1124/jpet.109.157560. Epub 2009 Aug 17.
4
Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors.G蛋白偶联受体的激动剂结合、激动剂亲和力和激动剂效能
Br J Pharmacol. 2008 Apr;153(7):1353-63. doi: 10.1038/sj.bjp.0707672. Epub 2008 Jan 28.

本文引用的文献

1
Molecular Architecture of G Protein-Coupled Receptors.G蛋白偶联受体的分子结构
Drug Dev Res. 1996 Jan 1;37(1):1-38. doi: 10.1002/(SICI)1098-2299(199601)37:1<1::AID-DDR1>3.0.CO;2-S.
2
G-protein coupled receptors: conformations and states.G蛋白偶联受体：构象与状态
Biochem Pharmacol. 1999 Oct 1;58(7):1081-8. doi: 10.1016/s0006-2952(99)00144-6.
3
Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors.结合、门控、亲和力与效能：激动剂的构效关系解读及受体突变效应
Br J Pharmacol. 1998 Nov;125(5):924-47. doi: 10.1038/sj.bjp.0702164.
4
Three-state and two-state models.三态和二态模型。
Trends Pharmacol Sci. 1998 Mar;19(3):85-6. doi: 10.1016/s0165-6147(98)01175-4.
5
Functional microdomains in G-protein-coupled receptors. The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor.G蛋白偶联受体中的功能微区。促性腺激素释放激素受体中保守的精氨酸笼基序。
J Biol Chem. 1998 Apr 24;273(17):10445-53. doi: 10.1074/jbc.273.17.10445.
6
The energetics of ligand binding at catecholamine receptors.儿茶酚胺受体处配体结合的能量学
Trends Pharmacol Sci. 1996 Jul;17(7):238-44. doi: 10.1016/0165-6147(96)10025-0.
7
Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation.5-羟色胺2受体的定点诱变：确定配体结合和受体激活所需的氨基酸
Mol Pharmacol. 1993 Jun;43(6):931-40.
8
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.与鸟嘌呤核苷酸调节蛋白偶联的受体的组成性活性。
Trends Pharmacol Sci. 1993 Aug;14(8):303-7. doi: 10.1016/0165-6147(93)90048-O.
9
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.β2肾上腺素能受体的突变诱导激活状态。扩展三元复合物模型。
J Biol Chem. 1993 Mar 5;268(7):4625-36.
10
Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.
J Biol Chem. 1988 Jul 25;263(21):10267-71.