Maratou E, Theophilidis G
Laboratory of Animal Physiology, School of Biology, Aristotle University, Thessaloniki, Greece.
Neuroscience. 2000;96(1):1-2. doi: 10.1016/s0306-4522(99)00529-1.
One of the main principles in neuroscience is that in vertebrate motoneurons and certain interneurons the decision to initiate an action potential is made at the initial segment of the axon, the axon hillock [Kandel E. R. and Schwartz J. H. (1991) In Principles of Neural Science (eds Kandel E. R., Schwartz J. H. and Jessell T. M. ), pp. 166-167. Elsevier, New York]. The situation in invertebrate motoneurons is different. The axon has many arborizations near its soma, in the nearby neuropil, and many branches in the target region. The action potentials are generated in the region of the axon in the neuropil and in some cases the trigger zone can be found more than 1mm apart from the soma [Tauc C. (1962) Aplysia. J. gen. Physiol. 45, 1077-1097]. Thus, it is obvious that, in a neuron, the removal of the trigger zone would cease the spiking activity in the axon. The purpose of this work is to demonstrate that, in snails, there are axons of certain neurons, like neuron B2, which are able to maintain their firing activity after the removal of their cell body and the so-called trigger zone.
神经科学的主要原理之一是，在脊椎动物的运动神经元和某些中间神经元中，引发动作电位的决定是在轴突的起始段，即轴丘做出的[坎德尔·E.R.和施瓦茨·J.H.（1991年）。《神经科学原理》（坎德尔·E.R.、施瓦茨·J.H.和杰塞尔·T.M.编），第166 - 167页。爱思唯尔出版社，纽约]。无脊椎动物运动神经元的情况则不同。轴突在其胞体附近、附近的神经纤维网中有许多分支，并且在靶区域有许多分支。动作电位在神经纤维网中的轴突区域产生，在某些情况下，触发区可在距胞体1毫米以上的地方找到[陶克·C.（1962年）。《海兔》。《普通生理学杂志》45卷，1077 - 1097页]。因此，很明显，在一个神经元中，去除触发区会使轴突中的脉冲发放活动停止。这项工作的目的是证明，在蜗牛中，某些神经元的轴突，如B2神经元，在去除其细胞体和所谓的触发区后仍能维持其放电活动。
