[儿童急性白血病细胞转铁蛋白受体表达分析]
[An analysis of acute leukemia cells TfR expression in children].
作者信息
Huang G, Liao Q, Luo C, Li F, Fu R
机构信息
Lab of Pediatrics Hemology and Oncology, Second Affiliated Hospital, Chengdu.
出版信息
Hua Xi Yi Ke Da Xue Xue Bao. 1997 Mar;28(1):55-7.
There are a lot of transferrin receptors on the acute leukemia cells. We used the method of "Receptor Radioligand Assay" to determine the numbers of TfR binding sites on leukemia cells from 20 child patients with acute lymphocyte leukemia (ALL) and 9 with acute myeloid leukemia (AML). The results showed the numbers of TfR binding sites of AML cells were higher than those of ALL cells, and the numbers of complete remission group were lower than those of dead or relapse group. This indicated there might be a relationship between the TfR expression and the prognosis.
急性白血病细胞上有大量转铁蛋白受体。我们采用“受体放射配体分析法”测定了20例儿童急性淋巴细胞白血病（ALL）患者和9例急性髓细胞白血病（AML）患者白血病细胞上转铁蛋白受体（TfR）结合位点的数量。结果显示，AML细胞的TfR结合位点数量高于ALL细胞，完全缓解组的数量低于死亡或复发组。这表明TfR表达与预后之间可能存在关联。
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