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香蕉花的降血糖活性:对四氧嘧啶糖尿病大鼠脂质过氧化的影响。

Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats.

作者信息

Pari L, Umamaheswari J

机构信息

Department of Biochemistry, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu, India.

出版信息

Phytother Res. 2000 Mar;14(2):136-8. doi: 10.1002/(sici)1099-1573(200003)14:2<136::aid-ptr607>3.0.co;2-k.

DOI:10.1002/(sici)1099-1573(200003)14:2<136::aid-ptr607>3.0.co;2-k
PMID:10685115
Abstract

Musa sapientum commonly known as 'banana' is widely used in Indian folk medicine for the treatment of diabetes mellitus. Oral administration of 0.15, 0.20 and 0.25 g/kg body weight of the chloroform extract of the flowers for 30 days resulted in a significant reduction in blood glucose and glycosylated haemoglobin and an increase in total haemoglobin. The extract prevented a decrease in body weight, and also resulted in a decrease in free radical formation in the tissues. Thus the study shows that banana flower extract (BFEt) has an antihyperglycaemic action. The decrease in thiobarbituric acid reactive substances (TBARS) and the increase in reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) clearly shows the antioxidant property of BFEt. The effect of BFEt was more prominently seen in the case of animals given 0.25 g/kg body weight. BFEt was more effective than glibenclamide.

摘要

香蕉(学名:Musa sapientum)在印度民间医学中广泛用于治疗糖尿病。连续30天口服剂量为0.15、0.20和0.25克/千克体重的香蕉花氯仿提取物,可显著降低血糖和糖化血红蛋白水平,并提高总血红蛋白水平。该提取物可防止体重减轻,还能减少组织中自由基的形成。因此,该研究表明香蕉花提取物(BFEt)具有降血糖作用。硫代巴比妥酸反应性物质(TBARS)的减少以及还原型谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的增加清楚地表明了BFEt的抗氧化特性。在给予0.25克/千克体重的动物中,BFEt的效果更为显著。BFEt比格列本脲更有效。

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