新生儿筛查确诊为囊性纤维化后的生育决策。
Reproductive decisions after neonatal screening identifies cystic fibrosis.
作者信息
Dudding T, Wilcken B, Burgess B, Hambly J, Turner G
机构信息
Hunter Genetics, Hunter Area Health Service, PO Box 84, Waratah, 2298 NSW, Australia.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2000 Mar;82(2):F124-7. doi: 10.1136/fn.82.2.f124.
AIMS
To document the reproductive choices made by women in New South Wales, Australia, after neonatal screening has identified cystic fibrosis (CF).
METHODS
A sample of women attending cystic fibrosis clinics in New South Wales who had a child (or children) diagnosed by neonatal screening between 1981 and 1996 were interviewed.
RESULTS
Two thirds of the women chose to avoid having another child with CF. The uptake of prenatal diagnosis was 66% in women who had a subsequent pregnancy; of these 69% terminated or would have terminated an affected fetus. Fifty nine per cent of the women who decided against a further pregnancy made this decision in order to avoid having another child with CF.
CONCLUSIONS
These data show that having a child with CF influenced subsequent reproductive choices. In addition to the medical advantages of an early diagnosis offered by neonatal screening, this also allows informed future reproductive decisions.
目的
记录在澳大利亚新南威尔士州新生儿筛查确诊为囊性纤维化（CF）后，女性所做出的生育选择。
方法
对1981年至1996年间在新南威尔士州囊性纤维化诊所就诊、其子女经新生儿筛查确诊为CF的女性样本进行访谈。
结果
三分之二的女性选择避免再生育患CF的孩子。后续怀孕的女性中，产前诊断的接受率为66%；其中69%终止或会终止受影响胎儿的妊娠。决定不再怀孕的女性中，59%做出这一决定是为了避免再生育患CF的孩子。
结论
这些数据表明，生育患CF的孩子会影响后续的生育选择。除了新生儿筛查提供的早期诊断的医学优势外，这也有助于未来做出明智的生育决定。
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