Wistar白化大鼠神经节苷脂中GM1、GD1a、GT1b成分的年龄相关性变化。

Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats.

作者信息

Aydin M, Cengiz S, Agaçhan B, Yilmaz H, Isbir T

机构信息

Institute of Experimental Medicine Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey.

出版信息

Cell Biochem Funct. 2000 Mar;18(1):41-5. doi: 10.1002/(SICI)1099-0844(200001/03)18:1<41::AID-CBF846>3.0.CO;2-W.

DOI:10.1002/(SICI)1099-0844(200001/03)18:1<41::AID-CBF846>3.0.CO;2-W

PMID:10686582

Abstract

In this study, age-related changes of GM1, GD1a, GT1b fractions of gangliosides were investigated in whole brain of male Wistar albino rats. Insignificant increases were detected in GM1 values from the third to the 24th month, whereas GD1a and GT1b concentrations of ganglioside in 24-month-old rats decreased significantly as compared to 6-month-old rats. Although there were no significant differences in the GD1a/GT1b ratio of any groups, GM1/GD1a and GM1/GT1b ratios were significantly increased as compared to 6-month-old rats. The increase in the ratios of gangliosides are not due to an increase of GM1 fractions; they result from a decrease of GD1a and GT1b fractions of gangliosides. In conclusion, the concentration of ganglioside decreased with ageing.

摘要

在本研究中，对雄性Wistar白化大鼠全脑的神经节苷脂GM1、GD1a、GT1b组分的年龄相关变化进行了研究。从第3个月到第24个月，GM1值检测到无显著增加，而24月龄大鼠神经节苷脂的GD1a和GT1b浓度与6月龄大鼠相比显著降低。尽管任何组的GD1a/GT1b比值均无显著差异，但与6月龄大鼠相比，GM1/GD1a和GM1/GT1b比值显著增加。神经节苷脂比值的增加并非由于GM1组分增加；而是由于神经节苷脂的GD1a和GT1b组分减少所致。总之，神经节苷脂浓度随衰老而降低。