超氧化物歧化酶-硫酸软骨素复合物在大鼠动脉损伤模型中的抗血栓活性。
Antithrombotic activity of the superoxide dismutase-chondroitin sulfate complexes in a rat model of arterial injury.
作者信息
Maksimenko A V, Tischenko E G, Golubykh V L
机构信息
Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow, Russia.
出版信息
Cardiovasc Drugs Ther. 1999 Nov;13(6):479-84. doi: 10.1023/a:1007815418082.
Individual antithrombotic activities of superoxide dismutase (SOD) and sodium chondroitin sulfate (CHS) as well as the activities of covalent and noncovalent complexes of SOD with CHS were compared in a rat model of arterial thrombosis induced by ferrous chloride. Covalent conjugate of SOD with CHS exerted the most potent antithrombotic effect, which was associated with adsorption of the conjugate on the glycocalyx of the vascular wall cells and stability of the covalent bond between CHS and SOD subunits. Theoretical and practical directions in the investigation of SOD and CHS preparations are outlined.
在氯化亚铁诱导的大鼠动脉血栓形成模型中，比较了超氧化物歧化酶（SOD）和硫酸软骨素钠（CHS）的个体抗血栓活性，以及SOD与CHS共价和非共价复合物的活性。SOD与CHS的共价缀合物具有最强的抗血栓作用，这与缀合物在血管壁细胞糖萼上的吸附以及CHS与SOD亚基之间共价键的稳定性有关。概述了SOD和CHS制剂研究的理论和实践方向。
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