[超氧化物歧化酶与硫酸软骨素复合物在大鼠动脉损伤中的抗血栓活性]
[Antithrombotic activity of complexes of superoxide dismutase with chondroitin sulfate in arterial damage in rats].
作者信息
Maksimenko A V, Tishchenko E G, Golubykh V L
机构信息
Institute of Experimental Cardiology, Russian Cardiology Research Centre, Moscow, Russia.
出版信息
Vopr Med Khim. 1998 Jul-Aug;44(4):353-61.
The comparative antithrombotic activity of superoxide dismutase and chondroitin sulfate in the form of covalent or noncovalent complexes was studied on the rat arterial thrombosis induced by treatment of vessel with ferrous chloride solution. The covalent conjugate between superoxide dismutase and chondroitin sulfate has been shown to exert the highest antithrombotic effect. The higher antithrombotic activity of covalent conjugate is stipulated by its coupling on the glycocalyx of vascular wall and by the stability of the covalent bond between superoxide dismutase subunits and chondroitin sulfate.
研究了超氧化物歧化酶与硫酸软骨素以共价或非共价复合物形式存在时，对用氯化亚铁溶液处理血管诱导的大鼠动脉血栓形成的抗血栓活性比较。超氧化物歧化酶与硫酸软骨素之间的共价缀合物已显示出最高的抗血栓作用。共价缀合物较高的抗血栓活性是由其在血管壁糖萼上的偶联以及超氧化物歧化酶亚基与硫酸软骨素之间共价键的稳定性所决定的。
Zotero 插件