Haux J
Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim.
Med Hypotheses. 1999 Dec;53(6):543-8. doi: 10.1054/mehy.1999.0985.
The ability of digitalis to block cell proliferation has been well established for some time. Recently, digitalis in non-toxic concentrations has been showed to induce apoptosis in different malignant cell lines. In light of the pivotal role of apoptosis in cancer development and progression and this new experimental finding concerning digitalis, it seems probable that the apoptosis-inducing capability is explained by mechanisms other than just Na+/K+ ATPase inhibition. In this article, features of the cardiac glycosides which make them interesting to evaluate further as potential anticancer drugs are discussed. Some new data concerning inhibition and apoptosis in three human glioblastoma cell lines by digitoxin are also presented.
洋地黄抑制细胞增殖的能力在一段时间以来已得到充分证实。最近，已显示无毒浓度的洋地黄可诱导不同恶性细胞系发生凋亡。鉴于凋亡在癌症发生和发展中的关键作用以及有关洋地黄的这一新实验发现，诱导凋亡的能力似乎很可能是由除抑制钠钾ATP酶之外的其他机制所解释。本文讨论了强心苷的一些特性，这些特性使其作为潜在抗癌药物值得进一步评估。还介绍了有关地高辛对三种人胶质母细胞瘤细胞系的抑制作用和凋亡的一些新数据。
