Noguchi M, Kido Y, Kubota H, Kinjo H, Kohama G
Department of Oral Surgery, Sapporo Medical University School of Medicine, Japan.
Br J Oral Maxillofac Surg. 1999 Dec;37(6):433-7. doi: 10.1054/bjom.1999.0146.
The records of 136 patients with N1-3 oral squamous cell carcinoma treated by surgery were investigated retrospectively, with the aim of finding out which factors were predictive of survival on multivariate analysis. Four independent factors significantly influenced survival in the following order: pN stage; T stage; histological grade; and N stage. The most significant was pN stage, the five-year survival for patients with pN0 being 91% and for patients with pN1-3 41%. A further study was carried out on the 80 patients with pN1-3 to find out their prognostic factors for survival and the independent factors identified by multivariate analysis were T stage and presence or absence of extracapsular spread to metastatic lymph nodes.
对136例接受手术治疗的N1-3期口腔鳞状细胞癌患者的记录进行了回顾性研究，目的是找出在多变量分析中哪些因素可预测生存情况。四个独立因素对生存有显著影响，顺序如下：病理N分期；T分期；组织学分级；以及N分期。最显著的是病理N分期，pN0患者的五年生存率为91%，pN1-3患者为41%。对80例pN1-3患者进行了进一步研究，以找出其生存的预后因素，多变量分析确定的独立因素为T分期以及转移淋巴结有无包膜外扩散。
