Branigan E F, Estes M A
Bellingham IVF and Infertility Center, Bellingham, Washington, USA.
Fertil Steril. 2000 Mar;73(3):587-90. doi: 10.1016/s0015-0282(99)00584-1.
To determine if oral contraceptive pill (OC) pre-treatment prior to minimal stimulation IVF using clomiphene citrate (CC) would make the procedure easier to perform by preventing the LH surge and result in pregnancy rates (PRs) comparable to stimulated IVF.
Prospective cohort study.
Private tertiary infertility center.
PATIENT(S): Thirty-two women with tubal or pelvic adhesive disease as the cause of their infertility, ovulatory cycles, under the age of 40, and no male factor.
INTERVENTION(S): Two-month ovarian-hypothalamic-pituitary axis suppression with OC followed by CC 100 mg on day 3 of the cycle for 8 days, hCG administration midcycle, follicle aspiration, IVF, and embryo transfer.
MAIN OUTCOME MEASURE(S): Oocytes retrieved, serum LH and estradiol levels, maturity of oocytes, fertilization rates, embryo number and quality, and PRs.
RESULT(S): Thirty-six patients completed 71 stimulation cycles and 64 follicle aspirations. No LH surges occurred with a mean mature oocytes retrieved of 3.2, 90% fertilization rate, and mean 2.5 embryos transferred. Twenty-one of the 64 cycles resulted in a clinical pregnancy (32.8% PR per retrieval) with 2 other biochemical pregnancies and 3 twin gestations. This was not significantly different from the matched cohort stimulated IVF.
CONCLUSION(S): Minimal stimulation IVF is a simple, low-cost, and low-risk alternative to stimulated IVF with comparable PRs.
确定在使用枸橼酸氯米芬（CC）进行轻度刺激体外受精（IVF）之前，口服避孕药（OC）预处理能否通过预防促黄体生成素（LH）峰使该操作更易于实施，并使妊娠率（PR）与刺激IVF相当。
前瞻性队列研究。
私立三级不孕不育中心。
32名因输卵管或盆腔粘连疾病导致不孕、排卵周期正常、年龄在40岁以下且无男性因素的女性。
用OC抑制卵巢-下丘脑-垂体轴两个月，随后在周期第3天给予100mg CC，持续8天，周期中期注射人绒毛膜促性腺激素（hCG），卵泡抽吸，IVF及胚胎移植。
获卵数、血清LH和雌二醇水平、卵母细胞成熟度、受精率、胚胎数量和质量以及PR。
36名患者完成了71个刺激周期和64次卵泡抽吸。未出现LH峰，平均获成熟卵母细胞3.2个，受精率90%，平均移植胚胎2.5个。64个周期中有21个临床妊娠（每次抽吸的PR为32.8%），另有2例生化妊娠和3例双胎妊娠。这与匹配队列的刺激IVF无显著差异。
轻度刺激IVF是一种简单、低成本、低风险的替代刺激IVF的方法，妊娠率相当。
