Messmann H
Klinik und Poliklinik für Innere Medizin I, Universität Regensburg.
Z Gastroenterol. 2000 Jan;38(1):21-30. doi: 10.1055/s-2000-14846.
Fluorescence endoscopy is a new technique which allows a better endoscopic detection of nonvisible or difficult detectable malignant or premalignant lesions. Exogenously applied sensitizers accumulate selectively in malignant lesions and induce fluorescence after illumination with light of adequate wavelength. However, also endogenous fluorophores, different located in malignant or benign lesions, induce a different autofluorescence in these tissues. Meanwhile fluorescence endoscopy is a widely spread technique in urology using 5-aminolevulinic acid sensitization. In gastroenterology this technique seems promising in the detection of early cancers or dysplasia in patients with Barrett's esophagus or ulcerative colitis. This paper describes the current status and future development of fluorescence endoscopy in gastroenterology.
荧光内镜检查是一项新技术，它能更好地在内镜下检测不可见或难以检测到的恶性或癌前病变。外源性应用的敏化剂选择性地在恶性病变中蓄积，并在适当波长的光照射后诱导产生荧光。然而，位于恶性或良性病变中的不同内源性荧光团也会在这些组织中诱导产生不同的自发荧光。同时，荧光内镜检查是泌尿外科广泛应用的一项技术，采用5-氨基酮戊酸敏化。在胃肠病学领域，这项技术在检测巴雷特食管或溃疡性结肠炎患者的早期癌症或发育异常方面似乎很有前景。本文描述了荧光内镜检查在胃肠病学领域的现状和未来发展。
