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高频喷射通气与气体潴留

High frequency jet ventilation and gas trapping.

作者信息

Spackman D R, Kellow N, White S A, Seed P T, Feneck R O

机构信息

Department of Anaesthesia, St Thomas' Hospital, Guy's and St Thomas' NHS Trust, London, UK.

出版信息

Br J Anaesth. 1999 Nov;83(5):708-14. doi: 10.1093/bja/83.5.708.

DOI:10.1093/bja/83.5.708
PMID:10690131
Abstract

We have compared three types of high frequency jet ventilation (HFJV) with conventional positive pressure ventilation in patients recovering from elective coronary artery bypass surgery. Twelve patients were allocated randomly to receive HFJV at ventilatory frequencies of 60, 100, 150 and 200 bpm from a standard jet ventilator at either the proximal or distal airway (HFJV.p and HFJV.d), or from a valveless high frequency jet ventilator acting as a pneumatic piston (VPP). Trapped gas volume (Vtr), cardiac index (CI) and right ventricular ejection fraction (RVEF) were measured. Vtr was related to the type of HFJV used (P < 0.05) and ventilatory frequency (P < 0.05). CI decreased with increasing rate of HFJV (P < 0.05) and there were significant differences between the three types of HFJV (P < 0.05). RVEF showed a linear relationship with ventilatory frequency (P < 0.05) decreasing most with the VPP. The decrease in RVEF was associated with an increase in right ventricular end-systolic volume (P < 0.05) suggesting that an increase in right ventricular afterload was the cause. The same three types of HFJV were compared using a lung model with variable values of compliance and resistance, to assess the impact of lung mechanics on gas trapping (Vtr, ml). Lung model compliance (C) was set at 50 or 25 ml cm H2O-1 and resistance (R) at 5 or 20 cm H2O litre-1 s, where values of 50 and 5, respectively, are normal. Vtr increased with ventilatory frequency for all types of jet ventilation (P < 0.05), varying with the type of jet ventilation used (P < 0.05).

摘要

我们将三种高频喷射通气(HFJV)与择期冠状动脉搭桥手术后恢复中的患者的传统正压通气进行了比较。12名患者被随机分配,分别通过标准喷射呼吸机在近端或远端气道以60、100、150和200次/分钟的通气频率接受HFJV(HFJV.p和HFJV.d),或通过作为气动活塞的无阀高频喷射呼吸机(VPP)接受HFJV。测量了潴留气体量(Vtr)、心脏指数(CI)和右心室射血分数(RVEF)。Vtr与所使用的HFJV类型有关(P<0.05)且与通气频率有关(P<0.05)。CI随着HFJV频率的增加而降低(P<0.05),并且三种HFJV类型之间存在显著差异(P<0.05)。RVEF与通气频率呈线性关系(P<0.05),在VPP模式下降低最为明显。RVEF的降低与右心室收缩末期容积的增加有关(P<0.05),提示右心室后负荷增加是其原因。使用具有不同顺应性和阻力值的肺模型对相同的三种HFJV类型进行比较,以评估肺力学对气体潴留(Vtr,毫升)的影响。肺模型顺应性(C)设定为50或25毫升/厘米水柱-1,阻力(R)设定为5或20厘米水柱/升-1秒,其中50和5的值分别为正常情况。对于所有类型的喷射通气,Vtr均随通气频率增加(P<0.05),且因所使用的喷射通气类型而异(P<0.05)。

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