Hobai I A, Levi A J
Bristol Heart Institute, Department of Physiology, School of Medical Sciences, University of Bristol, UK.
Cardiovasc Res. 1999 Dec;44(3):477-87. doi: 10.1016/s0008-6363(99)00236-9.
In heart muscle, strong evidence shows that excitation-contraction coupling involves Ca-induced Ca-release. However, under some conditions, single heart cells show Ca release and contraction which is not correlated with Ca entry via the Ca channel, suggesting a second Ca-independent release mechanism. Similar observations were made in early, pioneering studies using voltage-clamped multi-cellular preparations. We review the influence that experimental preparations and conditions have had on excitation-contraction coupling theory over the last 20 years.
在心肌中，有力的证据表明兴奋 - 收缩偶联涉及钙诱导的钙释放。然而，在某些情况下，单个心肌细胞会出现钙释放和收缩，这与通过钙通道的钙内流无关，提示存在第二种不依赖钙的释放机制。在早期使用电压钳制的多细胞制剂进行的开创性研究中也有类似的观察结果。我们回顾了过去20年中实验制剂和条件对兴奋 - 收缩偶联理论的影响。
