Sinnaeve P, Varenne O, Collen D, Janssens S
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU-Leuven, Belgium.
Cardiovasc Res. 1999 Dec;44(3):498-506. doi: 10.1016/s0008-6363(99)00259-x.
This update reviews the remarkable progression in several cardiovascular gene transfer domains. The first chemical gene therapy protocols to stimulate angiogenesis in ischemic myocardium are discussed and both the great expectations as well as remaining hurdle are highlighted. In experimental models of restenosis and heart failure gene therapy shows promising results. Important question regarding vector-related limitations and suboptimal in vivo delivery systems will require expeditious attention for gene therapy to become a more widely applicable option in cardiovascular diseases.
本综述回顾了多个心血管基因转移领域的显著进展。讨论了首批用于刺激缺血心肌血管生成的化学基因治疗方案，并强调了巨大的期望以及尚存的障碍。在再狭窄和心力衰竭的实验模型中，基因治疗显示出有前景的结果。关于载体相关局限性和体内递送系统欠佳等重要问题，需要尽快予以关注，以便基因治疗成为心血管疾病中更广泛适用的选择。
