Shimura T, Takebe K, Kano K, Suzuki H, Hagihara M, Asao T, Kuwano H
Department of Surgery I, Gunma University School of Medicine, Japan.
Hepatogastroenterology. 2000 Jan-Feb;47(31):251-5.
BACKGROUND/AIMS: While allogeneic organ transplantation has been performed safely, a major barrier in xenogeneic transplantation is how to inhibit hyperacute rejection.
We challenged xenogeneic fetal liver transplantation from pig to dog. The graft was investigated by immunohistochemical analysis on recipient's IgG, IgM and C3.
In 1 of 4 cases, the graft escaped hyperacute rejection for about 4 hours after transplantation, however, the recipient died next day due to hemorrhage from the torn capsule of the liver due to the arterial blood pressure of the recipient. Histologically, the parenchyma showed good countenance and no congestion nor hemorrhage was shown in the vessels. On immunohistochemical analysis, canine IgG, IgM and C3 were deposited on the sinusoidal epithelium of the fetal liver more moderately than that of adult control. Fetal porcine liver showed less expression of major histocompatability complex class I antigen than that of the adult one.
We consider that the hyperacute rejection occurred more slowly in xenogeneic fetal liver transplantation than in the adult one due to not only less expression of major histocompatability complex class I, but also lower expression of the epitope recognized by a natural antibody of the recipient.
背景/目的：虽然同种异体器官移植已安全开展，但异种移植的一个主要障碍是如何抑制超急性排斥反应。
我们对猪到犬的异种胎儿肝移植进行了研究。通过对受体的IgG、IgM和C3进行免疫组织化学分析来研究移植物。
在4例中有1例，移植物在移植后约4小时逃脱了超急性排斥反应，然而，受体第二天因受体动脉血压导致肝包膜撕裂出血而死亡。组织学上，实质表现良好，血管未见充血和出血。免疫组织化学分析显示，犬IgG、IgM和C3在胎儿肝窦状上皮的沉积比成年对照更适度。胎儿猪肝主要组织相容性复合体I类抗原的表达比成年猪肝少。
我们认为，异种胎儿肝移植中超急性排斥反应的发生比成年肝移植更缓慢，这不仅是因为主要组织相容性复合体I类抗原的表达较少，还因为受体天然抗体识别的表位表达较低。
