早期人类胎儿肝脏中的牛磺酸、甘氨酸及各胆汁酸
Hepatic taurine, glycine and individual bile acids in early human fetus.
作者信息
Itoh S, Onishi S
机构信息
Department of Pediatrics, Kagawa Medical University, Miki, Kitagun, Japan.
出版信息
Early Hum Dev. 2000 Jan;57(1):71-7. doi: 10.1016/s0378-3782(99)00053-5.
OBJECTIVE
To examine 3alpha-hydroxy individual bile acid and the association between taurine and taurine-conjugated bile acid in human fetal liver.
METHODS
Taurine, glycine and the individual bile acids in liver samples taken from 17 human fetuses whose abortion was induced from 12 to 23 weeks' gestation were determined by high-performance liquid chromatography.
RESULTS
The concentrations of taurine, glycine and bile acids in early fetal life were not related to gestational age. Hepatic taurine was statistically correlated with total taurine-conjugates (r = 0.798; P < 0.0001), but hepatic glycine was not correlated with glycine-conjugates (r = -0.103; P > 0.05). Lithocholic acid was conjugated exclusively with taurine.
CONCLUSIONS
Our results supported that in human fetal life there is a considerable bile acid pool in liver, and that taurine works effectively on the bile acid metabolism depending on the hepatic taurine concentration.
目的
检测人胎肝中3α-羟基个别胆汁酸以及牛磺酸与牛磺酸结合型胆汁酸之间的关联。
方法
采用高效液相色谱法测定从17例妊娠12至23周人工流产的人胎儿肝脏样本中牛磺酸、甘氨酸及个别胆汁酸的含量。
结果
胎儿早期牛磺酸、甘氨酸及胆汁酸的浓度与胎龄无关。肝脏牛磺酸与总牛磺酸结合物呈统计学相关（r = 0.798；P < 0.0001），但肝脏甘氨酸与甘氨酸结合物无相关性（r = -0.103；P > 0.05）。石胆酸仅与牛磺酸结合。
结论
我们的结果支持在人胎儿期肝脏中存在相当数量的胆汁酸池，并且牛磺酸根据肝脏牛磺酸浓度对胆汁酸代谢发挥有效作用。
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