Brubaker R F, Ingram C J, Schoff E O, Nau C B
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Ophthalmology. 2000 Feb;107(2):283-7. doi: 10.1016/s0161-6420(99)00044-5.
To compare the efficacy of combinations of betaxolol-brinzolamide and timolol-dorzolamide as suppressors of aqueous humor flow and ocular hypotensive agents.
Placebo-controlled, masked comparison of the two drug combinations.
Twenty-five normal human volunteers with the fellow eye serving as control. METHODS OR TESTING: Fluorophotometric measurement of aqueous humor flow and pneumatonometric measurement of intraocular pressure.
Aqueous humor flow and intraocular pressure.
The betaxolol-brinzolamide combination lowered aqueous flow 39% to 44%, and the timololdorzolamide combination lowered aqueous flow 51%. The betaxolol-brinzolamide combination lowered intraocular pressure 14% to 19%, and the timolol-dorzolamide combination lowered it 18% to 24%.
Both drug combinations were effective; the timolol-dorzolamide combination appeared to be the more effective of the two after short-term exposure (24 hours).
比较倍他洛尔-布林佐胺组合与噻吗洛尔-多佐胺组合作为房水生成抑制剂和降眼压药物的疗效。
对两种药物组合进行安慰剂对照、双盲比较。
25名正常人类志愿者，另一只眼作为对照。
用荧光光度法测量房水生成，用眼压计测量眼压。
房水生成和眼压。
倍他洛尔-布林佐胺组合使房水生成降低39%至44%，噻吗洛尔-多佐胺组合使房水生成降低51%。倍他洛尔-布林佐胺组合使眼压降低14%至19%，噻吗洛尔-多佐胺组合使眼压降低18%至24%。
两种药物组合均有效；短期（24小时）使用后，噻吗洛尔-多佐胺组合似乎更有效。
