Duncan C C, Rumsey J M, Wilkniss S M, Denckla M B, Hamburger S D, Odou-Potkin M
Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD 20892, USA.
Psychophysiology. 1994 Jul;31(4):386-401. doi: 10.1111/j.1469-8986.1994.tb02447.x.
Event-related brain potentials (ERPs) were recorded from a group of 13 men with severe developmental dyslexia and 15 matched normal controls. Auditory and visual stimuli, presented in separate reaction time tasks of graded difficulty, were used to elicit ERPs. No group differences in P300 were seen under relatively undemanding task conditions. However, as task demands increased, visual P300 was reduced in the dyslexic men as compared with the normal readers. An Abbreviated Conners Parent Rating Scale was used to assess retrospectively childhood symptoms of attention-deficit hyperactivity disorder (ADHD). Additional analyses revealed that the dyslexics with a history of many symptoms of ADHD in childhood (high ADHD) accounted for the group differences in P300; the dyslexics with a history of few or no such symptoms (low ADHD) were indistinguishable from the controls at all electrode sites. Furthermore, whereas the low-ADHD dyslexics showed the same hemispheric asymmetry in auditory P300 as did the controls (right > left), auditory P300 was more symmetrically distributed in the high-ADHD dyslexics. The results are interpreted as suggesting that a distinct brain organization may characterize dyslexic men with a history of concomitant deficits in attention.
对一组13名患有严重发育性阅读障碍的男性和15名匹配的正常对照者记录了事件相关脑电位（ERP）。在分级难度的单独反应时间任务中呈现听觉和视觉刺激，以诱发ERP。在要求相对较低的任务条件下，未观察到两组在P300上的差异。然而，随着任务要求的增加，与正常阅读者相比，阅读障碍男性的视觉P300降低。使用简化的康纳斯父母评定量表对注意力缺陷多动障碍（ADHD）的儿童期症状进行回顾性评估。进一步的分析表明，童年时有许多ADHD症状史（高ADHD）的阅读障碍者导致了P300的组间差异；童年时有很少或没有此类症状史（低ADHD）的阅读障碍者在所有电极部位与对照组无差异。此外，低ADHD阅读障碍者在听觉P300上表现出与对照组相同的半球不对称性（右>左），而高ADHD阅读障碍者的听觉P300分布更对称。结果被解释为表明一种独特的脑组织结构可能是有伴随注意力缺陷史的阅读障碍男性的特征。
