Idiazábal Alecha M, Palencia Taboada A B, Sangorrín J, Espadaler-Gamissans J M
Servicio de Neurofisiolog a; Hospital Universitario del Mar, Barcelona, 08003, Espana.
Rev Neurol. 2002;34(4):301-5.
The Attention Deficit Hyperactivity Disorder, ADHD, is characterized by deficient attention, impulsiveness and excessive motor activity. The incidence is estimated between 5 and 9% of children of school age. The P300 wave is one of the cognitive components of the event related potential ( ERP) that is more used to investigate the attention and the cognitive processes.
The aim of this study was to investigate the information processing in children with ADHD predominantly inattentive type by means of the visual and auditory P300 component.
P300 wave using an auditory and visual oddball paradigm were recorded in 18 children with ADHD and in 18 normal children ( control group ).
We found differences in reaction time and in the percentage of errors between children with ADHD and between controls. In the ADHD the latency of the auditory and visual P300 were significantly longer than in the control group, and the amplitude of both components were significantly smaller in the ADHD group than in controls. We didn t found differences in the cortical distribution of the P300 between the two groups.
These data suggests that there is an abnormal processing of cognitive information in children with ADHD predominantly inattentives and a dysfunction in attentional mechanisms.
注意力缺陷多动障碍(ADHD)的特征是注意力不集中、冲动和过度的运动活动。据估计,学龄儿童的发病率在5%至9%之间。P300波是事件相关电位(ERP)的认知成分之一,更多地用于研究注意力和认知过程。
本研究的目的是通过视觉和听觉P300成分来研究以注意力不集中为主型ADHD儿童的信息处理情况。
对18名ADHD儿童和18名正常儿童(对照组)使用听觉和视觉oddball范式记录P300波。
我们发现ADHD儿童与对照组之间在反应时间和错误百分比上存在差异。在ADHD儿童中,听觉和视觉P300的潜伏期明显长于对照组,且两组中这两个成分的波幅在ADHD组中明显小于对照组。我们未发现两组之间P300的皮层分布存在差异。
这些数据表明,以注意力不集中为主型的ADHD儿童存在认知信息处理异常和注意力机制功能障碍。