美罗培南单独及与万古霉素联合用于耐青霉素肺炎球菌菌株所致实验性脑膜炎的研究。
Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain.
作者信息
Gerber C M, Cottagnoud M, Neftel K A, Täuber M G, Cottagnoud P
机构信息
Department of Internal Medicine, Inselspital, Berne, Switzerland.
出版信息
Eur J Clin Microbiol Infect Dis. 1999 Dec;18(12):866-70. doi: 10.1007/s100960050421.
In a rabbit model of meningitis caused by a pneumococcus highly resistant to penicillin (MIC, 4 microg/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (-0.48+/-0.14 deltalog10 cfu/ml h) and slightly superior to ceftriaxone (-0.34+/-0.23 deltalog10 cfu/ml x h) and vancomycin (-0.39+/-0.19 deltalog10 cfu/ml x h). Although the combination of vancomycin with ceftriaxone was significantly more active than ceftriaxone alone (-0.55+/-0.19 deltalog10 cfu/ml x h), only an insignificant gain was observed by the addition of vancomycin to meropenem (-0.55+/-0.28 deltalog10 cfu/ml x h).
在由对青霉素高度耐药（最低抑菌浓度，4微克/毫升）的肺炎球菌引起的兔脑膜炎模型中，美罗培南，一种广谱碳青霉烯类药物，具有杀菌作用（-0.48±0.14对数10菌落形成单位/毫升·小时），略优于头孢曲松（-0.34±0.23对数10菌落形成单位/毫升·小时）和万古霉素（-0.39±0.19对数10菌落形成单位/毫升·小时）。虽然万古霉素与头孢曲松联合使用比单独使用头孢曲松活性显著更高（-0.55±0.19对数10菌落形成单位/毫升·小时），但在美罗培南中添加万古霉素仅观察到微不足道的增效（-0.55±0.28对数10菌落形成单位/毫升·小时）。
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