伴有平滑肌分化的睾丸旁脂肪肉瘤，酷似血管平滑肌脂肪瘤。
Paratesticular liposarcoma with smooth muscle differentiation mimicking angiomyolipoma.
作者信息
Womack C, Turner A G, Fisher C
机构信息
Department of Histopathology/Cytology; Urology, Peterborough District Hospital, Peterborough, UK.
出版信息
Histopathology. 2000 Mar;36(3):221-3. doi: 10.1046/j.1365-2559.2000.00840.x.
AIMS
To discuss the differential diagnosis of a case of well-differentiated liposarcoma which had areas resembling angiomyolipoma-a feature which, to our knowledge, has not been reported previously.
METHODS AND RESULTS
A tumour in the paratesticular region had apparently been present for 40 years, but had grown recently. A fat component containing lipoblasts was admixed with areas resembling angiomyolipoma, i.e. desmin positive, but HMB45-negative smooth muscle proliferation with atypia and thick-walled blood vessels devoid of elastin.
CONCLUSION
The diagnosis of liposarcoma, rather than angiomyolipoma with adipose atypia, in this case is based on the fact that smooth muscle differentiation is documented in liposarcoma, lack of HMB45 staining and recent clonality studies which suggest that the fat in angiomyolipoma is not neoplastic.
目的
探讨一例高分化脂肪肉瘤病例的鉴别诊断，该病例存在类似血管平滑肌脂肪瘤的区域——据我们所知，此前尚无此特征的相关报道。
方法与结果
一例睾丸旁区域的肿瘤显然已存在40年，但近期有所生长。含脂肪母细胞的脂肪成分与类似血管平滑肌脂肪瘤的区域混合存在，即结蛋白阳性，但HMB45阴性的非典型平滑肌增生以及无弹性蛋白的厚壁血管。
结论
该病例诊断为脂肪肉瘤而非伴有脂肪异型性的血管平滑肌脂肪瘤，依据如下：脂肪肉瘤中有平滑肌分化的记录、缺乏HMB45染色以及近期的克隆性研究表明血管平滑肌脂肪瘤中的脂肪并非肿瘤性的。
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