大肠杆菌ada基因稳定整合对酿酒酵母对烷基化剂毒性和诱变作用敏感性的影响。 - Suppr | 超能文献

Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents.

作者信息

Farkasová E, Chovanec M, Vlasáková D, Vlcková V, Margison G P, Brozmanová J

机构信息

Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic.

出版信息

Environ Mol Mutagen. 2000;35(1):66-9. doi: 10.1002/(sici)1098-2280(2000)35:1<66::aid-em9>3.3.co;2-u.

DOI:10.1002/(sici)1098-2280(2000)35:1<66::aid-em9>3.3.co;2-u

Abstract

摘要

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Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents.大肠杆菌ada基因稳定整合对酿酒酵母对烷基化剂毒性和诱变作用敏感性的影响。

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An E. coli ada transgenic clone of Nicotiana tabacum var. Xanthi has increased sensitivity to the mutagenic action of alkylating agents, maleic hydrazide and gamma-rays.烟草品种Xanthi的大肠杆菌ada转基因克隆对烷基化剂、马来酰肼和γ射线的诱变作用敏感性增加。

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A region of the Ada DNA-repair protein required for the activation of ada transcription is not necessary for activation of alkA.激活ada转录所需的Ada DNA修复蛋白区域对于激活alkA并非必需。

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Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability.在缺乏和具备DNA修复蛋白O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）的细胞中，烷基化诱变剂对c-fos、c-jun、junB和junD信使核糖核酸（mRNA）及活化蛋白-1（AP-1）的诱导作用及其与细胞死亡、诱变和染色体不稳定性的关系。

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Expression of the E.coli ada gene in S.cerevisiae provides cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine in rad6 but not in rad52 mutants.大肠杆菌ada基因在酿酒酵母中的表达赋予rad6突变体而非rad52突变体细胞对N-甲基-N'-硝基-N-亚硝基胍的抗性。

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Expression of the E.coli ada gene in yeast protects against the toxic and mutagenic effects of N-methyl-N'-nitro-N-nitrosoguanidine.大肠杆菌ada基因在酵母中的表达可抵御N-甲基-N'-硝基-N-亚硝基胍的毒性和诱变作用。

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How heterologously expressed Escherichia coli genes contribute to understanding DNA repair processes in Saccharomyces cerevisiae.异源表达的大肠杆菌基因如何有助于理解酿酒酵母中的DNA修复过程。

Curr Genet. 2004 Dec;46(6):317-30. doi: 10.1007/s00294-004-0536-2. Epub 2004 Nov 13.