Visioli F, Galli C, Bornet F, Mattei A, Patelli R, Galli G, Caruso D
Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy.
FEBS Lett. 2000 Feb 25;468(2-3):159-60. doi: 10.1016/s0014-5793(00)01216-3.
Olive oil phenolic constituents have been shown, in vitro, to be endowed with potent biological activities including, but not limited to, an antioxidant action. To date, there is no information on the absorption and disposition of such compounds in humans. We report that olive oil phenolics, namely tyrosol and hydroxytyrosol, are dose-dependently absorbed in humans after ingestion and that they are excreted in the urine as glucuronide conjugates. Furthermore, an increase in the dose of phenolics administered increased the proportion of conjugation with glucuronide.
橄榄油中的酚类成分在体外已显示具有多种强大的生物活性，包括但不限于抗氧化作用。迄今为止，尚无关于此类化合物在人体中的吸收和代谢情况的信息。我们报告称，橄榄油中的酚类物质，即酪醇和羟基酪醇，在摄入后会在人体中呈剂量依赖性吸收，并以葡萄糖醛酸苷结合物的形式随尿液排出。此外，酚类物质给药剂量的增加会使与葡萄糖醛酸结合的比例增加。
