Ong D E, Chytil F
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3976-8. doi: 10.1073/pnas.73.11.3976.
Cellular retinol-binding protein and cellular retinoic-acid-binding protein, canditates for mediating the action of vitamin A, were found to be present in tissues of the fetal rat. Cellular retinol-binding proteins were still present in most tissues of the adult, but the retinoic-acid-binding protein was not detected in some, including lung, liver, intestine, and kidney. During perinatal development of lung the level of cellular retinol-binding protein remained relatively constant while the level of the cellular retinoic-acid-binding protein peaked at 10 days postnatally, then declined. It was not detectable in lung tissue from 21-day-old rats. In liver, however, the retinoic-acid-binding protein was not detectable later than 5 days postnatally, while the level of the cellular retinol-binding proteinrose sharply near birth, declining only after 21 days to the lower adult levels. The variations observed in the levels of the two binding proteins suggest different and changing requirements for retinol and retinoic acid in organ development and maturation.
细胞视黄醇结合蛋白和细胞视黄酸结合蛋白被认为是介导维生素A作用的候选物质，它们在胎鼠组织中被发现。细胞视黄醇结合蛋白在成年动物的大多数组织中仍然存在，但视黄酸结合蛋白在包括肺、肝、肠和肾在内的一些组织中未被检测到。在肺的围产期发育过程中，细胞视黄醇结合蛋白的水平保持相对恒定，而细胞视黄酸结合蛋白的水平在出生后10天达到峰值，然后下降。在21日龄大鼠的肺组织中未检测到它。然而，在肝脏中，视黄酸结合蛋白在出生后5天之后就无法检测到，而细胞视黄醇结合蛋白的水平在出生时急剧上升，仅在21天后降至较低的成年水平。两种结合蛋白水平的变化表明，在器官发育和成熟过程中，对视黄醇和视黄酸的需求不同且不断变化。
