肺结核豚鼠模型中疫苗诱导抗性的机制 - Suppr

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Mechanisms of vaccine-induced resistance in a guinea pig model of pulmonary tuberculosis.

作者信息

McMurray D N, Dai G, Phalen S

机构信息

Department of Medical Microbiology and Immunology, Texas A&M University System Health Science Center 77843-1114, USA.

出版信息

Tuber Lung Dis. 1999;79(4):261-6. doi: 10.1054/tuld.1998.0207.

DOI:10.1054/tuld.1998.0207

PMID:10692995

Abstract

摘要

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Mechanisms of vaccine-induced resistance in a guinea pig model of pulmonary tuberculosis.肺结核豚鼠模型中疫苗诱导抗性的机制

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Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs.用表达 ESAT-6 的 DNA 疫苗（DNAE6）进行增强会消除重组卡介苗（rBCGE6）对豚鼠气溶胶分枝杆菌感染的保护作用。

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Mycobacterium bovis BCG vaccination augments interleukin-8 mRNA expression and protein production in guinea pig alveolar macrophages infected with Mycobacterium tuberculosis.牛分枝杆菌卡介苗接种增强感染结核分枝杆菌的豚鼠肺泡巨噬细胞中白细胞介素-8信使核糖核酸表达及蛋白质产生。

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