Wolfe B E, Metzger E D, Levine J M, Finkelstein D M, Cooper T B, Jimerson D C
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Neuropsychopharmacology. 2000 Mar;22(3):257-63. doi: 10.1016/S0893-133X(99)00117-7.
Abnormal serotonergic regulation in bulimia nervosa is thought to contribute to recurrent binge eating, depressed mood, and impulsivity. To follow-up on previous studies showing decreased neuroendocrine responses in symptomatic patients, this study assessed serotonin-mediated prolactin responses in individuals who had remitted from bulimia nervosa. Subjects included 21 women with a history of bulimia nervosa and 21 healthy female controls, as well as an additional comparison group of 19 women with current bulimia nervosa. Placebo-controlled neuroendocrine response studies utilized a single oral dose (60 mg) of the indirect serotonin agonist d,l-fenfluramine. For the bulimia nervosa remitted group, the fenfluramine-stimulated elevation in serum prolactin concentration was not significantly different from the response in healthy controls, but was significantly larger than the response in patients with current bulimia nervosa (p < .01). These findings suggest that diminished serotonergic neuroendocrine responsiveness in bulimia nervosa reflects a state-related abnormality. The results are discussed in relationship to recent reports indicating that some alterations in central nervous system serotonin regulation may persist in symptomatically recovered individuals.
神经性贪食症中异常的血清素调节被认为会导致反复的暴饮暴食、情绪低落和冲动行为。为了跟进之前显示有症状患者神经内分泌反应降低的研究，本研究评估了已从神经性贪食症康复的个体中血清素介导的催乳素反应。研究对象包括21名有神经性贪食症病史的女性和21名健康女性对照，以及另外一组由19名患有当前神经性贪食症的女性组成的对照组。安慰剂对照的神经内分泌反应研究使用了单次口服剂量（60毫克）的间接血清素激动剂d，l - 芬氟拉明。对于已康复的神经性贪食症组，芬氟拉明刺激引起的血清催乳素浓度升高与健康对照组的反应无显著差异，但显著大于当前患有神经性贪食症患者的反应（p < 0.01）。这些发现表明，神经性贪食症中血清素能神经内分泌反应性降低反映了一种与状态相关的异常。结合近期报告讨论了这些结果，这些报告表明中枢神经系统血清素调节的一些改变可能在症状恢复的个体中持续存在。
