Bruce Kenneth R, Steiger Howard, Young Simon N, Kin N M K Ng Ying, Israël Mimi, Lévesque Mélissa
Eating Disorders Program, Douglas Institute, Montréal, Canada.
J Psychiatry Neurosci. 2009 Sep;34(5):376-82.
Previous research has shown that many people experience a temporary worsening of mood following acute tryptophan depletion (ATD) and that concurrent use of serotonergic medications may influence such mood responses. We investigated mood and other consequences of ATD in women with bulimia nervosa who were or were not using concurrent serotonergic medications compared with women without bulimia.
Women self-referred for treatment of bulimia who were either not currently using psychoactive medications (n = 26) or who were using serotonin reuptake inhibitor medications exclusively (n = 13), as well as medication-free normal-eater control women (n = 25) completed interviews and questionnaires assessing eating and comorbid psychopathology and then participated in an ATD procedure involving balanced and tryptophan-depleted conditions.
In the tryptophan-depleted condition, the groups displayed similar and significant decrements in plasma tryptophan levels and mood. Women with bulimia who were using serotonin reuptake inhibitors, but not the other groups, also reported an increased urge to binge eat in the tryptophan-depleted condition.
Application of medication in participants with bulimia was not random.
Acute reductions in serotonin availability produced similar mood-reducing effects in bulimic and nonbulimic women. To the extent that ATD affected subjective experiences pertinent to eating (i.e., urge to binge eat), such effects appeared to depend upon ATD-induced competition with the therapeutic effects of serotonergic medications.
先前的研究表明，许多人在急性色氨酸耗竭（ATD）后会经历情绪的暂时恶化，并且同时使用血清素能药物可能会影响这种情绪反应。我们调查了神经性贪食症女性在ATD情况下的情绪及其他后果，这些女性正在或未同时使用血清素能药物，并与无神经性贪食症的女性进行比较。
自我转诊接受神经性贪食症治疗的女性，其中目前未使用精神活性药物的有26人，仅使用血清素再摄取抑制剂药物的有13人，以及未服用药物的正常饮食对照女性25人，完成了评估饮食和共病精神病理学的访谈和问卷调查，然后参与了一个涉及平衡和色氨酸耗竭条件的ATD程序。
在色氨酸耗竭的情况下，各组的血浆色氨酸水平和情绪均出现了相似且显著的下降。使用血清素再摄取抑制剂的神经性贪食症女性，但其他组没有，也报告在色氨酸耗竭情况下暴饮暴食的冲动增加。
对神经性贪食症参与者使用药物并非随机。
血清素可用性的急性降低在神经性贪食症和非神经性贪食症女性中产生了相似的情绪降低效果。就ATD影响与饮食相关的主观体验（即暴饮暴食的冲动）而言，这种影响似乎取决于ATD引发的与血清素能药物治疗效果的竞争。
