Ferko A, Páral J, Raupach J, Chovanec V, Krajina A, Mericka P, Pavcnik D, Uchida B, Slizová D, Krs O, Nozicka J
Department of Field Surgery, Military Medical Academy, Hradec Králové, Czech Republic.
J Vasc Interv Radiol. 2000 Jan;11(1):111-4. doi: 10.1016/s1051-0443(07)61291-3.
To evaluate expandable stents healed into vein wall as autologous vein stent-grafts for endoluminal grafting.
Balloon expandable stents were placed into external jugular veins of eight dogs. Stent and vein patency was followed by ultrasonography. Five weeks after stent placement, jugular veins with endothelialized stent were harvested. The autologous vein stent-grafts were divided into two groups. In group A, autologous vein stent-grafts (n = 3) were placed immediately into Baker solution for microscopic examination. In group B, autologous vein stent-grafts (n = 3) underwent mechanical manipulation; they were compressed, mounted on angioplasty balloon, pushed through a 9-F sheath and dilated. The autologous vein stent-graft endothelialization and changes after mechanical manipulation were evaluated by light and electron microscopy.
Stent placement was successful in seven dogs. One stent migrated into the pulmonary artery. One well placed stent was damaged by compression dressing and thrombosed. At 5 weeks, gross and microscopic examinations revealed the autologous vein stent-grafts were fully covered by a 0.115- +/- 0.036-mm-thick neointimal layer. Small wall thrombus was observed in one autologous vein stent-graft. Repeated manipulations did not result in any intimal damage or stent loosening in the autologous vein stent-grafts.
Expandable stents healed into a vein have potential to be used as autologous vein stent-grafts for endoluminal grafting without risk of disruption during percutaneous transcatheter introduction.
评估植入静脉壁并愈合的可扩张支架作为腔内移植的自体静脉支架移植物的效果。
将球囊可扩张支架置入8只犬的颈外静脉。通过超声检查支架和静脉的通畅情况。支架置入5周后，获取带有内皮化支架的颈静脉。将自体静脉支架移植物分为两组。A组，将自体静脉支架移植物（n = 3）立即放入贝克溶液中进行显微镜检查。B组，对自体静脉支架移植物（n = 3）进行机械操作；对其进行压缩，安装在血管成形术球囊上，通过9F鞘推送并扩张。通过光镜和电镜评估自体静脉支架移植物的内皮化情况以及机械操作后的变化。
7只犬的支架置入成功。1个支架迁移至肺动脉。1个位置良好的支架因压迫包扎受损并形成血栓。5周时，大体和显微镜检查显示自体静脉支架移植物完全被一层0.115±0.036mm厚的新生内膜层覆盖。在1个自体静脉支架移植物中观察到小的壁血栓。重复操作未导致自体静脉支架移植物出现任何内膜损伤或支架松动。
植入静脉并愈合的可扩张支架有潜力作为腔内移植的自体静脉支架移植物，在经皮导管引入过程中无破裂风险。
