Lockshin M D, Sammaritano L R, Schwartzman S
Hospital for Special Surgery, Weill/Cornell Medical College, New York, New York 10021, USA.
Arthritis Rheum. 2000 Feb;43(2):440-3. doi: 10.1002/1529-0131(200002)43:2<440::AID-ANR26>3.0.CO;2-N.
To test the Sapporo criteria for the classification of the antiphospholipid syndrome (APS).
We classified 243 consecutive patients who had clinical diagnoses of primary APS (n = 49), secondary APS (n = 26), systemic lupus erythematosus (SLE) without clinical APS (n = 131), and lupus-like disease without clinical APS (n = 37).
Sensitivity, specificity, positive predictive value, and negative predictive value were 0.71, 0.98, 0.95, and 0.88, respectively. False-negative findings were the result of patients being classified on the basis of minor criteria that were not included in the Sapporo criteria, such as livedo reticularis, thrombocytopenia, low-titer IgG or IgM anticardiolipin antibody, IgA anticardiolipin antibody, and anti-beta2-glycoprotein I antibody. Some patients with false-negative results were true seronegative cases.
The Sapporo criteria for APS compare favorably with the American College of Rheumatology criteria for SLE and are usable for clinical studies.
检验用于抗磷脂综合征（APS）分类的札幌标准。
我们对243例连续患者进行了分类，这些患者临床诊断为原发性APS（n = 49）、继发性APS（n = 26）、无临床APS的系统性红斑狼疮（SLE，n = 131）以及无临床APS的狼疮样疾病（n = 37）。
敏感性、特异性、阳性预测值和阴性预测值分别为0.71、0.98、0.95和0.88。假阴性结果是由于患者是根据未纳入札幌标准的次要标准进行分类的，如网状青斑、血小板减少、低滴度IgG或IgM抗心磷脂抗体、IgA抗心磷脂抗体以及抗β2糖蛋白I抗体。一些假阴性结果的患者是真正的血清阴性病例。
APS的札幌标准与美国风湿病学会的SLE标准相比具有优势，可用于临床研究。
