AY-25,674对大鼠被动性肺过敏反应的抑制作用。

Inhibition of passive lung anaphylaxis in the rat by AY-25,674.

作者信息

Greenberg R, Martel R R, Smorong K

出版信息

Can J Physiol Pharmacol. 1979 Jan;57(1):48-52. doi: 10.1139/y79-007.

Abstract

The antiallergic properties of AY-25,674 were studied in a model of passive lung anaphylaxis. AY-25,674 caused a dose-related inhibition of antigen-induced bronchoconstriction in the passively sensitized rat. AY-25,674 was found to be twice as potent as disodium cromoglycate (DSCG) when injected intravenously. The oral administration of AY-25,674 also effectively inhibited antigen-induced bronchoconstriction. A tachyphylactic effect of repeated administration was found when the rats were pretreated with a large dose of AY-25,674. The compound did not significantly antagonize the bronchoconstriction produced by 5-hydroxytryptamine. These results indicate that AY-25,674 is an orally effective antianaphylactic compound with a mode of action similar to that of DSCG in preventing allergic mediator release.

摘要

在被动性肺过敏模型中研究了AY - 25,674的抗过敏特性。AY - 25,674在被动致敏大鼠中引起了与剂量相关的抗原诱导支气管收缩抑制作用。静脉注射时，发现AY - 25,674的效力是色甘酸钠（DSCG）的两倍。口服AY - 25,674也能有效抑制抗原诱导的支气管收缩。当用大剂量的AY - 25,674预处理大鼠时，发现重复给药有快速耐受性效应。该化合物对5 - 羟色胺产生的支气管收缩没有明显拮抗作用。这些结果表明，AY - 25,674是一种口服有效的抗过敏化合物，其作用方式与DSCG在预防过敏介质释放方面相似。