Pasha O, Luby S P, Khan A J, Shah S A, McCormick J B, Fisher-Hoch S P
Department of Community Health Sciences, The Aga Khan University Medical College, Karachi, Pakistan.
Epidemiol Infect. 1999 Dec;123(3):515-8. doi: 10.1017/s0950268899002770.
Household members of people with hepatitis C are at increased risk of HCV infection. The prevalence and routes of transmission of HCV to household members in Hafizabad, Pakistan were investigated. Household members of 24 index cases were given a risk factor questionnaire, tested for HCV infection, and the risk factors between the infected and uninfected were compared. Twelve of 74 household members (16.2%) were seropositive for HCV antibody. This was 2(1/2) times the rate of infection in the general population (OR = 2.8; P = 0.01). None of the routes of transmission studied within the household was associated with an increased risk. Household members who received more than 4 injections per year were 11.9 times more likely to be infected than those who had not (P = 0.016). In Hafizabad, the greatest risk for HCV infection to household members of infected people is injections given by health-care workers rather than household contact with infected persons.
丙型肝炎患者的家庭成员感染丙肝病毒（HCV）的风险增加。对巴基斯坦哈菲扎巴德地区HCV在家庭成员中的传播率及传播途径进行了调查。对24例索引病例的家庭成员进行了风险因素问卷调查，并检测其HCV感染情况，比较了感染组与未感染组的风险因素。74名家庭成员中有12名（16.2%）HCV抗体血清学呈阳性。这是普通人群感染率的2.5倍（比值比=2.8；P=0.01）。家庭内研究的任何传播途径均未显示风险增加。每年接受超过4次注射的家庭成员感染的可能性是未接受注射者的11.9倍（P=0.016）。在哈菲扎巴德，感染人群的家庭成员感染HCV的最大风险来自医护人员注射，而非与感染者的家庭接触。
