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2
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3
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Vascular smooth muscle cells (VSMC) proliferation of streptozotocin-diabetic animals induced by diadenosine polyphosphates.链脲佐菌素诱导的糖尿病动物中，二磷酸腺苷多聚体诱导血管平滑肌细胞（VSMC）增殖。
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本文引用的文献

1
Identification and characterization of P(1), P(7)-Di(adenosine-5')-heptaphosphate from human platelets.人血小板中P(1)，P(7)-二（腺苷-5'）-七磷酸的鉴定与特性分析
J Biol Chem. 1999 Aug 20;274(34):23926-31. doi: 10.1074/jbc.274.34.23926.
2
Pharmacological characterization of recombinant human and rat P2X receptor subtypes.重组人源和大鼠P2X受体亚型的药理学特性
Eur J Pharmacol. 1999 Jul 2;376(1-2):127-38. doi: 10.1016/s0014-2999(99)00350-7.
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Selectivity of diadenosine polyphosphates for rat P2X receptor subunits.二腺苷多磷酸对大鼠P2X受体亚基的选择性。
Eur J Pharmacol. 1999 Feb 12;367(1):119-23. doi: 10.1016/s0014-2999(98)00976-5.
4
Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase.利用细胞表面附着的萤火虫荧光素酶检测活化血小板释放的局部三磷酸腺苷
Am J Physiol. 1999 Jan;276(1):C267-78. doi: 10.1152/ajpcell.1999.276.1.C267.
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Receptors for purines and pyrimidines.嘌呤和嘧啶受体。
Pharmacol Rev. 1998 Sep;50(3):413-92.
6
2',3'-O-(2,4,6- trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)--a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels.2',3'-O-(2,4,6-三硝基苯基)腺苷5'-三磷酸（TNP-ATP）——一种对大鼠肠系膜动脉P2X受体离子通道具有纳摩尔亲和力的拮抗剂。
Br J Pharmacol. 1998 Aug;124(7):1463-6. doi: 10.1038/sj.bjp.0702001.
7
Comparison of the actions of ATP and UTP and P(2X1) receptors in smooth muscle of the rat tail artery.大鼠尾动脉平滑肌中ATP、UTP及P(2X1)受体作用的比较
Eur J Pharmacol. 1998 Jun 12;351(1):139-44. doi: 10.1016/s0014-2999(98)00294-5.
8
Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets.人血小板中的腺苷（5'）寡磷酸 -（5'）鸟苷和鸟苷（5'）寡磷酸 -（5'）鸟苷
J Clin Invest. 1998 Feb 1;101(3):682-8. doi: 10.1172/JCI119882.
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Ecto-enzymatic hydrolysis of diadenosine polyphosphates by cultured adrenomedullary vascular endothelial cells.培养的肾上腺髓质血管内皮细胞对二腺苷多磷酸的胞外酶促水解作用。
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10
The interaction of diadenosine polyphosphates with P2x-receptors in the guinea-pig isolated vas deferens.双腺苷多磷酸与豚鼠离体输精管中P2x受体的相互作用。
Br J Pharmacol. 1997 May;121(1):57-62. doi: 10.1038/sj.bjp.0701099.

二腺苷多磷酸（Ap(n)As）和腺苷多磷酸鸟苷（Ap(n)Gs）对大鼠肠系膜动脉P2X受体离子通道的影响。

Effects of diadenosine polyphosphates (Ap(n)As) and adenosine polyphospho guanosines (Ap(n)Gs) on rat mesenteric artery P2X receptor ion channels.

作者信息

Lewis C J, Gitterman D P, Schlüter H, Evans R J

机构信息

Department of Cell Physiology and Pharmacology, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, UK.

出版信息

Br J Pharmacol. 2000 Jan;129(1):124-30. doi: 10.1038/sj.bjp.0702993.

DOI:10.1038/sj.bjp.0702993
PMID:10694211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1621118/
Abstract

Diadenosine polyphosphates (Ap(n)As, n=3 - 7) and adenosine polyphospho guanosines (Ap(n)Gs, n=3 - 6) are naturally occurring vasoconstrictor substances found in platelets. These vasoconstrictor actions are thought to be mediated through the activation of P2X receptors for ATP. The effects of Ap(n)As and Ap(n)Gs at P2X receptors on rat mesenteric arteries were determined in contraction studies and using the patch clamp technique on acutely dissociated artery smooth muscle cells. P2X(1) receptor immunoreactivity was detected in the smooth muscle layer of artery rings. The sensitivity to alpha,beta-methylene ATP and desensitizing nature of rat mesenteric artery P2X receptors correspond closely to those of recombinant P2X(1) receptors. Ap(4)A, Ap(5)A and Ap(6)A evoked concentration dependent P2X receptor inward currents which desensitized during the application of higher concentrations of agonist. The agonist order of potency was Ap(5)A> or = Ap(6)A> or = Ap(4)A >> Ap(3)A. Ap(2)A and Ap(7)A were ineffective. Similar results were obtained in contraction studies except for Ap(7)A which evoked a substantial contraction. Ap(n)Gs (n=2 - 6)(30 microM) evoked P2X receptor inward currents in mesenteric artery smooth muscle cells. Ap(n)Gs (n=4 - 6) were less effective than the corresponding Ap(n)A. This study shows that at physiologically relevant concentrations Ap(n)As and Ap(n)Gs can mediate contraction of rat mesenteric arteries through the activation of P2X(1)-like receptors. However the activity of the longer chain polyphosphates (n=6 - 7) may be overestimated in whole tissue studies due to metabolic breakdown to yield the P2X receptor agonists ATP and adenosine tetraphosphate. British Journal of Pharmacology (2000) 129, 124 - 130

摘要

二腺苷多磷酸（Ap(n)As，n = 3 - 7）和腺苷多磷酸鸟苷（Ap(n)Gs，n = 3 - 6）是血小板中天然存在的血管收缩物质。这些血管收缩作用被认为是通过ATP的P2X受体激活介导的。通过收缩研究以及对急性解离的动脉平滑肌细胞使用膜片钳技术，确定了Ap(n)As和Ap(n)Gs在大鼠肠系膜动脉P2X受体上的作用。在动脉环的平滑肌层中检测到P2X(1)受体免疫反应性。大鼠肠系膜动脉P2X受体对α,β-亚甲基ATP的敏感性和脱敏特性与重组P2X(1)受体的非常相似。Ap(4)A、Ap(5)A和Ap(6)A引起浓度依赖性的P2X受体内向电流，在应用更高浓度激动剂时这些电流会脱敏。激动剂的效价顺序为Ap(5)A≥Ap(6)A≥Ap(4)A >> Ap(3)A。Ap(2)A和Ap(7)A无效。除了Ap(7)A引起显著收缩外，在收缩研究中获得了类似结果。Ap(n)Gs（n = 2 - 6）（30 microM）在肠系膜动脉平滑肌细胞中引起P2X受体内向电流。Ap(n)Gs（n = 4 - 6）的效果不如相应的Ap(n)A。本研究表明，在生理相关浓度下，Ap(n)As和Ap(n)Gs可通过激活类似P2X(1)的受体介导大鼠肠系膜动脉的收缩。然而，在全组织研究中，较长链多磷酸盐（n = 6 - 7）的活性可能由于代谢分解产生P2X受体激动剂ATP和四磷酸腺苷而被高估。《英国药理学期刊》（2000年）129卷，124 - 130页