Ehrly A M
Acta Chir Scand Suppl. 1976;465:92-5.
Treatment of secondary Raynaud's disease must be a treatment of the impaired microcirculation in the ischemic tissue. It can be performed in 3 ways: 1) By treating the vasospastic component 2) By reconstruction of occlusions or stenosis in the greater arteries 3) By improvement of the flow properties of blood. While the first two types of treatment often give unsatisfactory results, a new rheological therapy using Ancrod seems to be successful. This drug, a purified fraction from a snake venom lowers the fibrinogen concentration in blood therapy improving the flow properties of blood and plasma. In 5 patients suffering from severe secondary Raynaud's disease Ancrod was injected subcutaneously for a 2-4 week period. Some days after starting the treatment, the ischemic pain was reduced and finally disappeared. The beneficial effect continued even after ending the treatment. The mode of action of this new drug has been discussed.
继发性雷诺氏病的治疗必须针对缺血组织中受损的微循环。其治疗方法有三种：1）治疗血管痉挛成分；2）重建大动脉中的闭塞或狭窄；3）改善血液的流动特性。虽然前两种治疗方法往往效果不尽人意，但一种使用安克洛酶的新流变学疗法似乎很成功。这种药物是从蛇毒中提纯的成分，能降低血液疗法中的纤维蛋白原浓度，改善血液和血浆的流动特性。对5名患有严重继发性雷诺氏病的患者皮下注射安克洛酶，为期2至4周。开始治疗几天后，缺血性疼痛减轻并最终消失。即使在治疗结束后，这种有益效果仍持续存在。人们对这种新药的作用方式进行了讨论。
