Serrou B, Dubois J B
Acta Cytol. 1976 Nov-Dec;20(6):577-81.
Lymphocytotoxicity using S3-Hela target cells has been studied in 20 cancer patients treated with ionizing radiation (head and neck, lung and breast cancers). Monolayer cultures of Hela cells were marked with radioactive 51 Chromium and cultured with non stimulated or phytohemagglutinin (PHA) stimulated lymphocytes. This study shows a spontaneous decrease of lymphocytotoxicity in cancer patients as compared with normal subjects and an immunodepressive effect of radiotherapy. We observe a significant decrease of lymphocytotoxicity for either stimulated or non-stimulated lymphocytes at the end of radiation treatment. Moreover one month after completion of radiotherapy a possible repair of a lymphocytoxicity seems to be related with a short-term (6 months) good prognosis.
利用S3 - 海拉靶细胞对20例接受电离辐射治疗的癌症患者（头颈癌、肺癌和乳腺癌）进行了淋巴细胞毒性研究。海拉细胞单层培养物用放射性51铬标记，并与未刺激或经植物血凝素（PHA）刺激的淋巴细胞一起培养。这项研究表明，与正常受试者相比，癌症患者的淋巴细胞毒性会自发降低，且放疗具有免疫抑制作用。我们观察到，在放疗结束时，无论是刺激淋巴细胞还是未刺激淋巴细胞，其淋巴细胞毒性均显著降低。此外，放疗完成后一个月，淋巴细胞毒性的可能修复似乎与短期（6个月）良好预后相关。
