Jeffery D R, Absher J, Pfeiffer F E, Jackson H
Department of Neurology, Wake Forest University School of Medicine, The Sticht Center, Medical Center Boulevard, Winston-Salem, North Carolina, NC 27157, USA.
Mult Scler. 2000 Feb;6(1):50-5. doi: 10.1177/135245850000600110.
Patients suffering from multiple sclerosis have a high frequency of cognitive deficits usually attributable to demyelination and axonal loss in the subcortical white matter. Neurologic abnormalities referable to cortical function are uncommon but have been described. The present study describes three patients with clinically definite MS with deficits in cognitive function referable to cortical location. Two of the patients underwent positron emission tomography and showed profound cortical hypometabolism adjacent to subcortical white matter lesions seen on MRI. This paper points out that neurologic deficits referable to cortical sites may be caused by subcortical white matter lesions and that cognitive dysfunction in patients with MS may progress rapidly in the absence of motoria deficits or other evidence of clinical deterioration. Multiple Sclerosis (2000) 6 50 - 55
患有多发性硬化症的患者通常因皮质下白质脱髓鞘和轴突丢失而出现高频认知缺陷。可归因于皮质功能的神经学异常并不常见，但已有相关描述。本研究描述了三名临床确诊为多发性硬化症且存在可归因于皮质部位认知功能缺陷的患者。其中两名患者接受了正电子发射断层扫描，结果显示与MRI上所见皮质下白质病变相邻的皮质存在严重代谢减退。本文指出，可归因于皮质部位的神经学缺陷可能由皮质下白质病变引起，并且多发性硬化症患者的认知功能障碍在无运动功能缺陷或其他临床恶化证据的情况下可能迅速进展。《多发性硬化症》（2000年）6 50 - 55
