Gasbarrini A, Cremonini F, Armuzzi A, Ojetti V, Candelli M, Di Campli C, Sanz-Torre E, Pola R, Gasbarrini G, Pola P
Medical Pathology, Universita Cattolica, Roma, Italy.
J Physiol Pharmacol. 1999 Dec;50(5):735-42.
Classical risk factors for cardiovascular and cerebrovascular diseases do not fully coincide with the prevalence of these conditions. Emerging evidences show that new factors may be predisposing for the development of ischemic events. It has been demonstrated that atherosclerosis has a strong inflammatory background; such state of chronic inflammation may be related to the presence of persistent infectious agent. Helicobacter pylori (H. pylori), among other microorganisms, has been extensively investigated for its possible role. Many molecular mechanisms have been hypothesized to explain its eventual action. Epidemiological studies do not exclude a correlation between the infection and cardiovascular and cerebrovascular diseases. Many confounding factors, however, make difficult a definitive evaluation of the huge number of data present in the literature. Moreover, various therapeutic studies have been attempted to show if antibiotic treatment improves prognosis in patients affected by ischemic heart disease. Still, none of these trials focused specifically on the effects of H. pylori eradication on the clinical progression of vascular lesions.
心血管和脑血管疾病的经典风险因素与这些疾病的患病率并不完全一致。新出现的证据表明，新的因素可能易引发缺血性事件。已经证明动脉粥样硬化有强烈的炎症背景；这种慢性炎症状态可能与持续感染因子的存在有关。幽门螺杆菌（H. pylori）以及其他微生物，因其可能发挥的作用而受到广泛研究。已经假设了许多分子机制来解释其最终作用。流行病学研究并不排除感染与心血管和脑血管疾病之间的关联。然而，许多混杂因素使得对文献中大量数据进行明确评估变得困难。此外，已经尝试了各种治疗研究以表明抗生素治疗是否能改善缺血性心脏病患者的预后。尽管如此，这些试验都没有专门关注根除幽门螺杆菌对血管病变临床进展的影响。
