Figura N, Perrone A, Gennari C, Orlandini G, Giannace R, Lenzi C, Vagliasindi M, Bianciardi L, Rottoli P
Institute of Internal Medicine, University of Siena, Italy.
J Physiol Pharmacol. 1999 Dec;50(5):827-31.
The aim of this study was to test whether patients with symptomatic food allergy and significant levels of immunoglobulin E (IgE) to alimentary antigens were more likely infected by H. pylori, especially by strains expressing the CagA protein, with respect to controls. A group of 38 patients with symptomatic food allergy and 53 age-matched controls were examined serologically for H. pylori infectious status, and for CagA seropositivity. IgE to alimentary allergens were measured by a commercial kit. The prevalence of H. pylori infection in patients with food allergy and controls was similar (42.1%, and 48.3%, respectively). However, anti-CagA antibodies in H. pylori-infected persons were detected in 62.5% of patients with food allergy, and 28% of controls (P = 0.030, odds ratio = 4.29). The mean level of IgE to the most common alimentary antigens in serum samples from infected patients with anti-CagA antibodies was significantly higher than in CagA-negative infected patients: 3.28 kU/L (SD 3.93), vs. 1.99 kU/L (SD 1.53), P = 0.002, 95% confidence interval = 0.61 to 2.53). Infection by CagA-positive H. pylori increases the risk of developing food allergy.
本研究的目的是检验有症状性食物过敏且对食物抗原具有高水平免疫球蛋白E（IgE）的患者相对于对照组是否更易感染幽门螺杆菌，尤其是感染表达细胞毒素相关基因A（CagA）蛋白的菌株。对一组38例有症状性食物过敏的患者和53例年龄匹配的对照组进行了幽门螺杆菌感染状况及CagA血清阳性的血清学检测。用商用试剂盒检测食物过敏原特异性IgE。食物过敏患者和对照组中幽门螺杆菌感染的患病率相似（分别为42.1%和48.3%）。然而，在幽门螺杆菌感染者中，食物过敏患者的抗CagA抗体检测率为62.5%，对照组为28%（P = 0.030，比值比 = 4.29）。抗CagA抗体阳性的感染患者血清样本中对最常见食物抗原的IgE平均水平显著高于抗CagA抗体阴性的感染患者：3.28 kU/L（标准差3.93），对比1.99 kU/L（标准差1.53），P = 0.002，95%置信区间 = 0.61至2.53）。感染CagA阳性幽门螺杆菌会增加发生食物过敏的风险。
