Lionetti Elena, Leonardi Salvatore, Lanzafame Angela, Garozzo Maria Teresa, Filippelli Martina, Tomarchio Stefania, Ferrara Viviana, Salpietro Carmelo, Pulvirenti Alfredo, Francavilla Ruggiero, Catassi Carlo
Elena Lionetti, Salvatore Leonardi, Angela Lanzafame, Maria Teresa Garozzo, Martina Filippelli, Stefania Tomarchio, Viviana Ferrara, Department of Pediatrics, University of Catania, 95100 Catania, Italy.
World J Gastroenterol. 2014 Dec 14;20(46):17635-47. doi: 10.3748/wjg.v20.i46.17635.
To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori (H. pylori), atopy and allergic diseases.
Studies published in English assessing the prevalence of atopy and/or allergic diseases in patients with H. pylori infection and the prevalence of H. pylori infection in patients with atopy and/or allergic diseases were identified through a MEDLINE search (1950-2014). Random-effect model was used for the meta-analysis.
Pooled results of case-control studies showed a significant inverse association of H. pylori infection with atopy/allergic disease or with exclusively atopy, but not with allergic disease, whereas pooled results of cross-sectional studies showed only a significant association between allergic disease and H. pylori infection.
There is some evidence of an inverse association between atopy/allergic diseases and H. pylori infection, although further studied are needed.
回顾并对现有关于幽门螺杆菌（H. pylori）、特应性素质和过敏性疾病之间关系的文献进行荟萃分析。
通过MEDLINE检索（1950 - 2014年），确定以英文发表的评估幽门螺杆菌感染患者中特应性素质和/或过敏性疾病患病率以及特应性素质和/或过敏性疾病患者中幽门螺杆菌感染患病率的研究。荟萃分析采用随机效应模型。
病例对照研究的汇总结果显示，幽门螺杆菌感染与特应性素质/过敏性疾病或仅与特应性素质呈显著负相关，但与过敏性疾病无显著负相关，而横断面研究的汇总结果仅显示过敏性疾病与幽门螺杆菌感染之间存在显著关联。
有证据表明特应性素质/过敏性疾病与幽门螺杆菌感染之间存在负相关，尽管还需要进一步研究。
