人类对日本血吸虫卵抗原的抗体同种型反应。
Human antibody isotype responses to Schistosoma japonicum egg antigen.
作者信息
Hu M, Kirinoki M, Yokoi H, Kawai S, Chigusa Y, Matsuda H
机构信息
Department of Medical Zoology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
出版信息
Southeast Asian J Trop Med Public Health. 1999 Mar;30(1):24-8.
Schistosoma japonicum-infected subjects from Hubei province of China were investigated to determine the class and subclass of the antibody response to soluble egg antigen (SEA), using an enzyme-linked immunosorbent assay. The subjects were 50 acute and 55 chronic cases. In acute cases, the mean OD values for IgA, IgE and IgG3 were very high, while the positive ratios of IgA and IgE were only 78% and 74%, respectively. The positive ratios of IgG, IgM, IgG1, IgG3 and IgG4 were all above 90%. In chronic cases, the mean OD values for IgG, IgG3 and IgG4 were very high, and the positivity rates of IgG, IgG1, IgG3 and IgG4 were all above 90%. Comparing the two study groups, the mean OD values of IgM, IgA, IgE were higher in acute cases than those of chronic cases (p < 0.0001), while the mean OD values of IgG, IgG4 were higher in chronic cases than in acute cases (p < 0.05). The mean OD values of IgG3 in both groups were high and those of IgG2 in both groups were low.
利用酶联免疫吸附测定法，对来自中国湖北省的日本血吸虫感染受试者进行了调查，以确定其对可溶性虫卵抗原（SEA）的抗体反应类别和亚类。受试者包括50例急性病例和55例慢性病例。在急性病例中，IgA、IgE和IgG3的平均光密度值非常高，而IgA和IgE的阳性率分别仅为78%和74%。IgG、IgM、IgG1、IgG3和IgG4的阳性率均高于90%。在慢性病例中，IgG、IgG3和IgG4的平均光密度值非常高，IgG、IgG1、IgG3和IgG4的阳性率均高于90%。比较两个研究组，急性病例中IgM、IgA、IgE的平均光密度值高于慢性病例（p<0.0001），而慢性病例中IgG、IgG4的平均光密度值高于急性病例（p<0.05）。两组中IgG3的平均光密度值较高，而两组中IgG2的平均光密度值较低。
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