Papacostas S
Cyprus Institute of Neurology and Genetics, Nicosia.
J Child Neurol. 2000 Feb;15(2):138-40. doi: 10.1177/088307380001500217.
Long-term treatment with carbamazepine is associated with many metabolic changes, including elevations in serum cholesterol, high-density lipoprotein, low-density lipoprotein, and triglyceride levels. Oxcarbazepine has been reported to be a preferable antiepileptic drug, when compared to carbamazepine with respect to its effects on lipid metabolism, especially cholesterol, high-density lipoproteins, and low-density lipoproteins. The case of a 16-year-old girl who developed high serum cholesterol and low-density lipoprotein levels on both of these medications successively, while triglyceride and high-density lipoprotein levels were unaffected, is reported.
长期使用卡马西平治疗会引发多种代谢变化，包括血清胆固醇、高密度脂蛋白、低密度脂蛋白及甘油三酯水平升高。据报道，与卡马西平相比，奥卡西平在脂质代谢，尤其是胆固醇、高密度脂蛋白和低密度脂蛋白方面的影响上，是一种更优的抗癫痫药物。本文报告了一名16岁女孩的病例，她先后在使用这两种药物时出现了高血清胆固醇和低密度脂蛋白水平，而甘油三酯和高密度脂蛋白水平未受影响。
