Sapadin A N, Gelfand J M, Howe K L, Phelps R G, Grand D, Rudikoff D
Department of Dermatology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
Cutis. 2000 Feb;65(2):85-8.
Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive cutaneous tumor of intermediate malignancy. Most commonly, it arises as an asymptomatic, indurated plaque on the trunk within which protuberant nodules develop over time. We describe its occurrence in two patients with human immunodeficiency virus, a previously unreported association. The first patient, a 41-year-old woman, complained of painful lesions around the left shoulder that developed within a scar from previous trauma to the area. The second patient, a 50-year-old man, developed a recurrent DFSP within the scar from a previous surgical procedure. Dermatofibrosarcoma protuberans was confirmed in both cases by the histopathologic and immunohistochemical findings.
隆突性皮肤纤维肉瘤（DFSP）是一种具有中度恶性的局部侵袭性皮肤肿瘤。最常见的情况是，它表现为躯干上无症状的硬结性斑块，随着时间推移，斑块内会出现突出的结节。我们描述了它在两名人类免疫缺陷病毒患者中的发生情况，这是一种此前未报告过的关联。第一名患者是一名41岁女性，主诉左肩周围出现疼痛性皮损，这些皮损在该区域先前创伤形成的瘢痕内出现。第二名患者是一名50岁男性，在先前手术瘢痕内出现了复发性DFSP。通过组织病理学和免疫组化结果，在这两例中均确诊为隆突性皮肤纤维肉瘤。
