化学减容后视网膜母细胞瘤的组织病理学变化
Histopathologic changes in retinoblastoma after chemoreduction.
作者信息
Dithmar S, Aabert T M, Grossniklaus H E
机构信息
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
出版信息
Retina. 2000;20(1):33-6. doi: 10.1097/00006982-200001000-00006.
PURPOSE
To report the histologic findings in the eyes of two patients with bilateral retinoblastoma who underwent chemoreduction therapy and enucleation of one eye.
METHODS
Clinical histories were obtained for both patients. The enucleated eyes were routinely processed and sections were stained with hematoxylin and eosin.
RESULTS
The first patient underwent two cycles of carboplatin, vincristine, and etoposide, and the second patient underwent one cycle of carboplatin, vincristine, and etoposide before enucleation. The eyes of both patients exhibited a clinical type 3 regression pattern. Histopathologic examination showed a gliotic mass with interspersed calcifications in one eye and necrotic tumor adjacent to histologically intact retinoblastoma in the other eye.
CONCLUSION
Chemoreduction has variable effects on retinoblastoma and the clinical type 3 regression pattern has several histologic counterparts.
目的
报告两名双侧视网膜母细胞瘤患者接受化学减灭疗法并摘除一眼后的眼部组织学检查结果。
方法
获取两名患者的临床病史。对摘除的眼球进行常规处理，切片用苏木精和伊红染色。
结果
第一名患者在摘除眼球前接受了两个周期的卡铂、长春新碱和依托泊苷治疗，第二名患者接受了一个周期的卡铂、长春新碱和依托泊苷治疗。两名患者的眼部均呈现临床3型消退模式。组织病理学检查显示，一只眼中有伴有散在钙化的胶质肿块，另一只眼中有与组织学上完整的视网膜母细胞瘤相邻的坏死肿瘤。
结论
化学减灭疗法对视网膜母细胞瘤有不同的效果，临床3型消退模式有多种组织学表现。
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