Katsumi Y, Hayashi T, Oyanagi C, Nagahama Y, Yamauchi H, Ono S, Fukuyama H, Shibasaki H
Department of Neurology, Graduate School of Medicine, Kyoto University, Japan.
Neurosci Lett. 2000 Feb 11;280(1):9-12. doi: 10.1016/s0304-3940(99)00993-3.
We measured the cerebral metabolic rate of glucose (CMRglc) by using positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) and the choline acetyltransferase (ChAT) activity at 3 days and 3 months after destruction of the nucleus basalis magnocellularis (NBM). Although the frontal ChAT activity remained 20% lower than that of controls even at 3 months post-lesioning, the frontal CMRglc, which was reduced by 40% at 3 days, returned to normal at 3 months, namely CMRglc recovered with time without the recovery of ChAT activity with time. Since glucose metabolism reflects mainly presynaptic neuronal activity, we speculate that presynaptic rearrangement may have some relation to the recovery of CMRglc.
我们通过使用正电子发射断层扫描（PET）和[18F]氟脱氧葡萄糖（FDG）来测量大脑葡萄糖代谢率（CMRglc），并在大细胞基底核（NBM）损毁后3天和3个月测量胆碱乙酰转移酶（ChAT）活性。尽管即使在损伤后3个月，额叶ChAT活性仍比对照组低20%，但额叶CMRglc在3天时降低了40%，在3个月时恢复正常，即CMRglc随时间恢复，而ChAT活性并未随时间恢复。由于葡萄糖代谢主要反映突触前神经元活动，我们推测突触前重排可能与CMRglc的恢复有关。
