Tokuuye K, Tokita N, Akine Y, Nakayama H, Sakurai Y, Kobayashi T, Kanda K
Radiation Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
Strahlenther Onkol. 2000 Feb;176(2):81-3. doi: 10.1007/pl00002332.
Cell survival assays were performed to evaluate the effects of radiations released during neutron capture reactions by gadolinium-157, boron-10 and by the combination of both.
Single cell suspensions with or without Gd-157 and/or B-10 were exposed to thermal neutrons produced by the Kyoto University reactor, and standard cell survival curves were obtained.
Under the same molarity, cytocidal effects were 1.5 times greater for Gd-157 than for boron when compared at 10% survival levels. The presence of B-10 enhanced the radiation effect of Gd-157 neutron capture by 1.2-fold, suggesting that cells were not sufficiently irradiated as a result of neutron fluency attenuation by the presence of excess neutron capture agents in the medium.
When an equal number of atoms were present, Gd-157 was effective as B-10 when exposed to an equal number of thermal neutrons. However, there was no benefit observed in the combination of Gd-157 and B-10 for neutron capture therapy. Further studies are needed to determine optimal Gd-157 and B-10 concentrations as a function of tumor dimension.
进行细胞存活试验，以评估钆 - 157、硼 - 10以及二者组合在中子俘获反应过程中释放的辐射的影响。
将含有或不含钆 - 157和/或硼 - 10的单细胞悬液暴露于京都大学反应堆产生的热中子下，获得标准细胞存活曲线。
在相同摩尔浓度下，在10%存活水平进行比较时，钆 - 157的杀细胞效果是硼的1.5倍。硼 - 10的存在使钆 - 157中子俘获的辐射效果增强了1.2倍，这表明由于培养基中存在过量的中子俘获剂导致中子通量衰减，细胞未得到充分照射。
当存在等量原子时，钆 - 157在暴露于等量热中子时与硼 - 10一样有效。然而，在中子俘获治疗中，未观察到钆 - 157和硼 - 10组合有任何益处。需要进一步研究以确定作为肿瘤大小函数的最佳钆 - 157和硼 - 10浓度。
